RBP circulates in the plasma bound to its carrier protein transthyretin (TTR) and this protein-protein complex is thought to interact with specific cell receptors to deliver retinol to the target …

Based on holo-RBP affinity for TTR and on their plasma concentrations (2 µM and 3.6–4.5 µM, respectively), it has been estimated that about 95% of circulating RBP is associated with TTR …

Transthyretin (TTR) is a tetrameric transport protein highly conserved through vertebrate evolution and synthesized in the liver, choroid plexus, and retinal pigment epithelium. TTR transports the …

1999年2月3日 · Whether ultimately utilized as retinoic acid, retinal, or retinol, vitamin A is transported to the target cells as all-trans-retinol bound to retinol-binding protein (RBP). …

Besides T 4, TTR is also the main carrier of retinol (vitamin A), by establishing a 1:1 molar complex with retinol binding protein (RBP), with binding being limited to a maximum of two …

1997年8月1日 · The mechanism by which cells take up retinol from retinol-binding protein (RBP) and the role of the RBP-transthyretin (TTR) complex remain unclear. Here we report on retinol …

2004年12月1日 · Retinol transport complex consisting of retinol-binding protein (RBP) and transthyretin (TTR) is involved in the transport of retinol (vitamin A) and thyroxine (T 4) in the …

1995年1月13日 · Tissue needs for retinoids are believed to be satisfied through the delivery in the circulation of retinol by its specific plasma transport protein, retinol-binding protein (RBP), …

1999年3月2日 · Whether ultimately utilized as retinoic acid, retinal, or retinol, vitamin A is transported to the target cells as all-trans-retinol bound to retinol-binding protein (RBP). …

Retinol-binding protein 4 (RBP4) is an adipokine bound in plasma to transthyretin (TTR), which prevents its glomerular filtration and subsequent catabolism in the kidney. Alterations of this …