Here, we evaluated the actions of TUDCA upon glucose-insulin homeostasis in aged C57BL/6 male mice (18-month-old) treated with 300 mg/kg of TUDCA or its vehicle. TUDCA attenuated hyperinsulinemia and improved glucose homeostasis in aged mice, by enhancing liver insulin-degrading enzyme (IDE) expression and insulin clearance.

2021年9月13日 · It is known that TUDCA reduces the accumulation of βA plaques in transgenic APP/PS1 AD mice model, in addition to decreasing the activation of astrocytes and microglia, which results in attenuation of neurotoxic potential and inflammatory response, as well as in decreased loss of neuronal integrity, altogether resulting in improved cognitive ...

2021年12月1日 · Bile acids have received increasing attention over the past years as their multiple alternative roles became clearer. Tauroursodeoxycholic Acid (TUDCA) in specific has generated special interest due to its ability to promote pancreatic survival and function, as well as reduce endoplasmic reticulum stress.

2021年5月1日 · Several studies have shown that TUDCA has neuroprotective action in several models of neurodegenerative disorders (ND), including Alzheimer's disease, Parkinson's disease, and Huntington's disease, based on its potent ability to inhibit apoptosis, attenuate oxidative stress, and reduce endoplasmic reticulum stress in different experimental ...

2021年2月5日 · TUDCA treatment improves glucose tolerance, insulin sensitivity and fasting and fed glycemia in Stz mice. Changes in blood glucose (A) and AUC of blood glucose (B) during ipGTT. Changes in blood glucose (C) and rate constant for glucose disappearance (kITT) (D) during the ipITT.

牛磺熊去氧胆酸 (TUDCA)，也称为 熊去氧牛磺酸，是一种天然存在的 胆汁酸衍生物，由熊去氧胆酸 (UDCA) 和 牛磺酸 在体内合成。 TUDCA 也可作为补充。 由于它可以调节细胞应激反应，TUDCA 可能具有多种治疗作用。 TUDCA 的主要益处是通过减少细胞应激和抑制炎症途径来维持细胞健康。 因此，TUDCA 被认为对多种疾病具有治疗作用，包括视网膜疾病、代谢疾病、肝脏相关疾病、神经退行性疾病（阿尔茨海默病 、 帕金森病 和 亨廷顿舞蹈症）和 肌萎缩侧索硬 …

Tauroursodeoxycholic Acid (TUDCA) in specific has generated special interest due to its ability to promote pancreatic survival and function, as well as reduce endoplasmic reticulum stress. However, there are few studies explaining the molecular mechanisms behind TUDCA's beneficial actions on pancreatic beta cells.

2021年9月13日 · Taken together, we demonstrate that TUDCA treatment restores energy metabolism in Stz mice, a phenomenon that is associated with reduced food intake, increased EE and improved hypothalamic leptin signaling. These findings suggest treatment with TUDCA as a promising therapeutic intervention for the control of energy homeostasis in AD individuals.

2021年2月5日 · The taurine conjugated bile acid, tauroursodeoxycholic (TUDCA), reduces amyloid oligomer accumulation and improves cognition in APP/PS1 mice model of AD, and also improves glucose-insulin homeostasis in obese and type 2 diabetic mice. Herein, we investigated the effect of TUDCA upon glucose metabolism in streptozotocin-induced AD mice model (Stz).

Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid containing taurine conjugated with the ursodeoxycholic acid (UDCA), has been known and used from ancient times as a therapeutic compound in traditional Chinese medicine. TUDCA has recently been gaining significant interest as a neuroprotective agent, also exploited in the visual disorders.