2017年6月19日 · Unlike PBA which reduces cell viability, TUDCA is cytoprotective and promotes mild UPR. Both chaperones mitigate activation of PERK-eIF2α-ATF4 arm of ER stress …

2010年10月1日 · The present study examined the effects of tauroursodeoxycholic acid (TUDCA), a known ER chaperone, on acinar function and UPR components. Isolated rat pancreatic acini …

Tauroursodeoxycholate (TUDCA; 2 mM) not only suppresses the expression of RPL11-induced ERS-related proteins but also markedly mitigates the expression of LC3-II and BECN1 and …

We found that TUDCA alleviated activating transcription factor 6 branch inhibition, partially enhanced protein kinase RNA-like ER kinase pathway activation, and repressed inositol …

In acute pancreatitis, endoplasmic reticulum (ER) stress prompts an accumulation of malfolded proteins inside the ER, initiating the unfolded protein response (UPR). Because the ER …

TUDCA interrupts the positive feedback from UPR-mediated apoptosis-induced hepatocarcinogenesis, leading to UPR activation by tumor microenvironmental stresses [11].

2016年12月22日 · To overcome this, we investigated the protective effect of tauroursodeoxycholic acid (TUDCA), a bile acid, on ER stress in MSCs in vitro and in vivo. In ER stress conditions, …

2025年1月28日 · Here, we found TUDCA can rescue growth of yeast treated with the ER stressor tunicamycin (Tm), even in the absence of a functional UPR. In contrast, TUDCA failed to …

2024年11月14日 · Here, we found TUDCA can rescue growth of yeast treated with the ER stressor tunicamycin (Tm), even in the absence of a functional UPR. In contrast, TUDCA failed …

2015年2月15日 · Tauroursodeoxycholic acid (TUDCA) a bile salt and chemical chaperone reduces stress-induced aggregation of proteins; activates PERK [PKR (RNA-dependent …