2024年12月25日 · TAOK2 (TAO Kinase 2) is a Protein Coding gene. Diseases associated with TAOK2 include Dyskeratosis Congenita, Autosomal Dominant 6 and Autism Spectrum …

Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the TAOK2 gene. [5] [6] [7]

2018年2月21日 · Whole-genome and -exome sequencing of ASD families identified three de novo mutations in TAOK2 and functional analysis in mice and human cells revealed that all the …

TAOK2 is an ER kinase that directly binds microtubules, coupling ER to microtubules. Loss of TAOK2 increases ER and microtubule dynamics. TAOK2 associates with EB1 and STIM1 to …

2024年4月12日 · Here, we use proteomics, genetics, and translation assays in cultured cells and mouse brain to reveal altered translation mediated by loss of the kinase TAOK2 in 16p11.2 …

taoks共有三个成员: taok1、taok2和taok3, 其结构域均高度保守, 广泛表达于多种细 胞和组织。作为丝裂原活化蛋白激酶(MAPK)级联的上游激酶, TAOKs通过p38 MAPK和JNK/SAPK

TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules. we characterize a compound that inhibits TAOK1 and TAOK2 activity with IC50 values of 11 to 15 …

TAOK2 is one of several genes in the 16p11.2 microdeletion region, but whether it contributes to NDDs is unknown. We performed behavioral analysis on Taok2 heterozygous (Het) and …

2017年1月18日 · We show that TAOK2 directly phosphorylates the cytoskeletal GTPase Septin7, at an evolutionary conserved residue. This phosphorylation induces translocation of Septin7 to …

该基因编码参与许多不同过程的丝氨酸/苏氨酸蛋白激酶，包括细胞信号传导、微管组织和稳定性以及细胞凋亡。 已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。 [RefSeq 提 …