TAT-11 was AT&T Corporation's 11th transatlantic telephone cable, in operation from 1993, initially carrying 2 x 565 Mbit/s between the United States and France. [1] The cable ran between Manahawkin, New Jersey, United States to Saint-Hilaire …

2024年12月23日 · 穿膜肽 tat 是一种源自人类免疫缺陷病毒（ hiv ）中的转录激活因子 tat 的蛋白质片段，具有卓越的细胞穿透能力，近年来在生物医学领域引起了广泛关注。

2019年4月18日 · Since the discovery that HIV Tat protein can penetrate mammalian cells and enter the nucleus 11, hundreds of peptides that have the capacity to enter cells have been identified and, to various...

2018年2月10日 · In this study, the cell-penetrating peptides (CPPs) bLFcin 6 and Tat 11 were separately conjugated to the antimicrobial peptide N2, and the antibacterial activity and pharmacodynamics of the CPPs-N2 conjugates were first evaluated against Salmonellae typhimurium in vitro and in macrophage cells.

2025年2月12日 · HIV-1 Tat plays an indispensable role in regulating viral transcription and is a promising target for achieving a functional cure for AIDS. Identifying the host factors that modulate Tat expression could benefit the development of anti-HIV-1 strategies targeting Tat.

2018年9月13日 · The poor penetration ability of antimicrobial agents limits their use in the treatment of intracellular bacteria. In this study, the conjugate CNC (6) was generated by connecting the cell-penetrating peptide Tat 11 (1) and marine peptide N6 (2) via a cathepsin-cleavable linker, and the C-t …

高效内吞作用可作用于多种靶细胞，且毒性低，这使得富含精氨酸的Tat肽（Tat 11 ：YGRKKRRQRRR，HIV-1 Tat蛋白的47-57位残基）成为递送的极佳转运蛋白。不幸的是，被内吞作用吸收的分子经历了内体包裹和可能的代谢降解。

抗菌剂渗透能力差，限制了它们在细胞内细菌治疗中的应用。在这项研究中，通过组织蛋白酶可切割的连接子连接细胞穿透肽tat 11（1）和海洋肽n6（2），以及c末端胺化n6（7）和cnc ，生成共轭cnc（6）。（8）首先被设计和合成以消除细胞内的鼠伤寒沙门氏菌。

Previous reports showed that the addition of an 11-amino acid stretch from the basic domain of Tat (amino acids 48–58, named tat11) to heterologous molecules, even of a large size, mediates...

We report a novel nontoxic, high-yield, gene delivery system based on the synergistic use of nanosecond electric pulses (NPs) and nanomolar doses of the recently introduced CM 18 -Tat 11 chimeric peptide (sequence of KWKLFKKIGAVLKVLTTGYGRKKRRQRRR, residues 1–7 of cecropin-A, 2–12 of melittin, and 47–57 of HIV-1 Tat protein).