2024年12月25日 · TBX4 (T-Box Transcription Factor 4) is a Protein Coding gene. Diseases associated with TBX4 include Ischiocoxopodopatellar Syndrome With Or Without Pulmonary …

Tbx4 is specifically expressed in the visceral mesoderm of the lung primordium and governs multiple processes during respiratory tract development such as initial endodermal bud …

The clinical phenotype of a TBX4 variant has recently been recognised to expand from bone disorders to different types of lung diseases. Recent data suggest that variants of TBX4, a …

TBX4Life - Global initiative to foster research for a cure for those affected by TBX4 Syndrome - genetic disorder causing Pulmonary Hypertension, chILD and skeletal issues

TBX4 (T-BOX transcription factor 4) is the second most common gene culprit for development of pulmonary arterial hypertension, especially in pediatric-onset cases. A growing body of …

Here, we discuss the developmental, tissue-specific, and pathological TBX4 functions identified through human and animal studies and review the published TBX4 variants resulting in …

Mutations of TBX4 (T-Box transcription factor 4 gene) on chromosome17q23.2 are associated with idiopathic and heritable PAH (4, 5) and small patellar syndrome (SPS) (6), underscoring …

2016年7月11日 · Here, we employed in vivo lineage tracing and real-time gene expression transgenic reporting methods to analyze the early embryonic transcription factor T-box gene 4 …

This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression …

1999年4月29日 · Here we show that Tbx4 and Tbx5 are essential regulators of limb outgrowth whose roles seem to be tightly linked to the activity of three signalling proteins that are …