2013年5月1日 · We demonstrate that Id2 restrains CD8(+) T cell memory differentiation by inhibiting E2A-mediated direct activation of Tcf7 and that Id2 expression level mirrors T cell …

T cell factor 1 (Tcf1, encoded by Tcf7) is the key transcription factor of the canonical Wnt signaling pathway (Figure 1A). The Wnt signaling pathway is evolutionarily conserved and regulates a …

2024年1月29日 · In the present study, we show that inhibitor of DNA binding protein 2 (Id2) transcriptionally and epigenetically promotes the generation of Slamf6 + Tex prog cells and …

2016年10月4日 · Tcf7 and Id2 were both strongly induced in the αLP, whereas ID2 expression was maintained in ILC2p, but Tcf7 expression was downregulated (Figure 4 A). These data …

2013年5月1日 · We demonstrate that Id2 restrains CD8 + T cell memory differentiation by inhibiting E2A-mediated direct activation of Tcf7 and that Id2 expression level mirrors T cell …

2021年4月15日 · Here, we demonstrated that ID2, a transcriptional regulatory protein constitutively expressed in NK cells, supports NK cell effector maturation by controlling the …

In contrast, Id2 was strongly anti-correlated with Tcf7. We then examined an extended list of TFs ( Figure 6 C). Two major clusters of TFs emerged, including one that contained Id3 , Eomes , …

2025年2月8日 · The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude. T Cell Factor 1 Suppresses CD103+ Lung Tissue-Resident …

2019年5月1日 · In natural killer (NK) cells, ID2 prevents immature cells from acquiring a naïve T cell – like gene program that restricts NK cell maturation and function. Here we show that Tcf7 …

使用Hobit reporter/deleter小鼠研究初次感染后病毒特异性TRM的分化途径和建立，发现Hobit识别了位于外周组织内的效应CD8+T细胞亚群，这些Hobit表达的效应T细胞形成TRM前体，产 …