The activating complexes are together called tenase. Tenase is a blend word of "ten" and the suffix "-ase", which means, that the complex activates its substrate (inactive factor X) by cleaving it. [1] Extrinsic tenase complex is made up of tissue factor, factor …

2023年2月9日 · 生理性的促凝从外源性通路起始，暴露在血管壁损伤部位的组织因子 (Tissue factor,TF)，TF激活并结合凝血因子7(FVII)，形成Tenase复合物，Tenase复合物进而激活因子10(FX)转变为FXa 。

The tenase complex converts factor X to factor Xa, the enzyme that converts prothrombin to thrombin leading to the conversion of fibrinogen to fibrin and the formation of a fibrin clot. This tenase complex cleaves FX at the same reactive site as that cleaved by the TF-FVIIa complex and hence produces the same FXa product.

Basic concept of blood coagulation. TF-FVIIa forms the extrinsic tenase complex and activates FIX to FIXa as well as FX to FXa. FXa-FVa forms the prothrombinase complex and converts prothrombin to thrombin. At this initiation stage of coagulation, only small amounts of thrombin are generated due to the low circulating levels of FVa.

2023年8月28日 · Tenase is the complex that cleaves factor X into factor Xa. Tenase has two forms: extrinsic, consisting of factor VII, factor III (tissue factor), and Ca2 + , or intrinsic, made up of cofactor factor VIII, factor IXA, a phospholipid, and Ca2 + .

2015年7月7日 · Intrinsic tenase, the final and rate-limiting enzyme complex in the intrinsic coagulation pathway, is an attractive but less explored target for anticoagulants due to the lack of a pure selective inhibitor.

2022年6月14日 · The intrinsic tenase (Xase) complex, formed by factors (f) VIIIa and fIXa, forms on activated platelet surfaces and catalyzes the activation of factor X to Xa, stimulating thrombin production in the blood coagulation cascade.

2008年8月28日 · What are the membrane surfaces on which the tenase and prothrombinase complexes assemble? It has been thought that the membrane surface that is critical for thrombin generation is presented by...

Once activated, factor IXa and factor Xa serve as the enzyme components of intrinsic tenase and prothrombinase, respectively. Because sufficient levels of factor Xa and thrombin are formed in response to exposure of tissue factor, the extrinsic tenase complex is considered the essential mediator of the initiation phase.

fX (Factor X) activation during blood coagulation occurs via two pathways: the extrinsic tenase complex formed by Factor VIIa and tissue factor, and the intrinsic tenase complex composed of fIXa (Factor IXa) and fVIIIa (Factor VIIIa) .