The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both sexes should be used.

As the trend towards the international dispersion of certain value chain activities produces challenges, discover policies to meet these

2018年6月27日 · OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies OECD The objective of these chronic toxicity studies is to characterize the profile of a substance...

Test No. 452: Chronic Toxicity Studies [electronic resource] Responsibility Organisation for Economic Co-operation and Development Imprint Paris : OECD Publishing, 2009. Physical description 16 p. ; 21x29.7cm. Series OECD Guidelines for the Testing of Chemicals, Section 4, 2074-5788. Online.

The objectives of this study are: to identify the chronic toxicity of a product; identify the target organs; characterize the dose-response relationship; identify a level of adverse effect not observed (NOAEL) or starting point for the establishment of a Reference Dose (BMD); predict the effects of chronic toxicity on human exposure levels; and ...

Yes, you can access Test No. 452: Chronic Toxicity Studies by OECD in PDF and/or ePUB format, as well as other popular books in Social Sciences & Sociology. We have over one million books available in our catalogue for you to explore.

The TAPPI T 452 Brightness test is used for the determination of the brightness of white, near-white, and naturally colored pulp, paper, and paperboard

The 452nd Flight Test Squadron is an active United States Air Force squadron. It is assigned to the 412th Operations Group of Air Force Materiel Command, stationed at Edwards Air Force Base, California, where it performs flight testing on unmanned aerial vehicles. The squadron was first activated as the 452nd Bombardment Squadron in July 1942.

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