2018年2月16日 · We conclude that Tet1 activity, determined by [O2] may play a critical role in regulating cellular differentiation and fate in embryogenesis. Graded levels of molecular …

Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene. Its function, regulation, and utilizable …

DNMT1是维持性DNA甲基转移酶,广泛分布于各种组织中,它更偏好作用于半甲基化的CpG位点,在细子(young retrotransposons)启动子区域建立甲基化,这一特定的甲基转移酶活性对小鼠的生育 …

2017年8月14日 · In this study, we sought to elucidate the biological function and mechanism of TET1 in trophoblast cells exposed to 3% O 2. We compared TET1 expression in villi and term …

2023年10月1日 · The expression of TET1 (a full-length protein) is most likely caused by a mutant form of p53 that cannot suppress its expression, unlike the wild type. In NSCLC cells, TET1 …

2011年3月30日 · Using chromatin immunoprecipitation coupled with high-throughput DNA sequencing, here we show in mouse ES cells that Tet1 is preferentially bound to CpG-rich …

DNA 甲基化是一种表观遗传机制，对控制基因表达很重要。 该基因编码的蛋白质是一种属于 TET (十-十一易位) 家族的去甲基化酶。 TET 蛋白家族的成员在 DNA 甲基化过程和基因激活中发 …

2017年12月12日 · Tet1-null zebrafish and mice are more sensitive to hypoxic conditions compared with their wild-type siblings. We demonstrate that Tet1 stabilizes hypoxia-inducible …

2017年12月15日 · We demonstrate that Tet1 stabilizes hypoxia-inducible factor α (HIF-α) and enhances HIF-α transcription activity independent of its enzymatic activity. In addition, we …

本文介绍了双加氧酶TET1的结构和去甲基化作用的机制，综述了其在胚胎发育、免疫应答、干细胞调控、癌症发展和神经系统发育等过程中发挥表观遗传调控作用的研究现状，并简述了其上游 …