2020年12月3日 · Lipopolysaccharide (LPS) increases extramitochondrial but not intramitochondrial TFAM abundance. LPS stimulation of PBMCs from healthy volunteers …

在最新的这项研究中，研究人员利用缺乏线粒体DNA复制所需关键蛋白 TFAM （线粒体转录因子A，mitochondrial transcription factor A）的小鼠模型，发现线粒体DNA缺失后，会导致炎性小 …

2024年5月23日 · In this Article, we identify the major mtDNA-bound protein TFAM as an autophagy receptor for nucleoid clearance. We demonstrate that TFAM interacts with …

TFAM reduced ROS and P38MAPK levels by inhibiting toll-like receptor 4 (TLR4) expression, ultimately inhibiting inflammation and repairing mtDNA. Conclusions: Our results indicate that …

2018年7月25日 · Transfection of synthetic D-loop ox-mtDNA into lipopolysaccharide (LPS)-primed TfamΔMye BMDMs induced IL-1β production without any known NLRP3 activator (Fig. 1a).

2017年1月1日 · The expression and the location of toll-like receptor 4 (TLR4) and mitochondrial transcription factor A (TFAM) were determined to reveal possible mechanisms. LPS-treated …

We found that diverse NLRP3 inflammasome activators rapidly stimulated uniporter-mediated calcium uptake to open mitochondrial permeability transition pores (mPTP) and trigger VDAC …

2023年4月15日 · Recent study showed that mitochondrial transcription factor A (TFAM) plays a crucial role in the maintenance of mitochondrial DNA and the production of ATP, and …

We found that mitochondrial transfer from MSCs to LPS-induced PMVECs through forming tunneling nanotubes (TNTs). Due to the inhibition of TNTs (using LAT-A), MSCs-mediated …

2011年12月1日 · Six to 48 h after LPS administration (5 mg/kg), liver mtDNA levels, respiratory complex I activity, and adenosine triphosphate (ATP) contents were decreased. In addition, …