转录因子EB(TFEB)的全方位综述 - 健康界
2022年8月19日 · 转录因子EB (TFEB)是自噬/溶酶体-核信号通路的中枢调控因子，参与能量稳态、应激反应、代谢、自噬和溶酶体生物发生等信号通路，与溶酶体储存障碍、神经退行性疾病、 …
SIRT6 is a key regulator of mitochondrial function in the brain
2023年1月18日 · Our analysis reveals that SIRT6 is a central regulator of mitochondrial activity in the brain. SIRT6 deficiency in the brain leads to mitochondrial deficiency with a global …
Autophagy︱杨倩课题组揭示转录因子TFEB入核调控新机制 - 知乎
转录因子EB （transcription factor EB，TFEB）属于碱性碱性螺旋-环-螺旋-亮氨酸拉链（bHLH-Zip）转录因子家族蛋白。研究表明TFEB能够直接结合于溶酶体基因的启动子， 促进溶酶体 …
【论肿道麻】Sirtuins: T细胞代谢和功能的重要调节因子|肿道|因子
2022年9月29日 · 最近的研究表明，Sirt6具有抗炎特性。Sirt6通过影响染色质结构而不是直接去乙酰化NF-κB来抑制促炎基因的转录，而Sirt1和Sirt2直接去乙酰化p65并抑制其转录活性。虽 …
SIRT6 regulates TNF-α secretion through hydrolysis of long
2013年4月3日 · We demonstrate further that SIRT6 promotes the secretion of tumour necrosis factor-α (TNF-α) by removing the fatty acyl modification on K19 and K20 of TNF-α. Protein …
MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 …
2023年8月29日 · Here, we report that the tumor-suppressive function of SIRT6 in non-small cell lung cancer (NSCLC) is regulated by acetylation. Specifically, males absent on the first (MOF) …
Biological and catalytic functions of sirtuin 6 as targets for small ...
2020年8月7日 · Sirtuin 6 (SIRT6) is a nuclear NAD +-dependent deacetylase of histone H3 that regulates genome stability and gene expression. However, nonhistone substrates and …
A Review of the Recent Advances Made with SIRT6 and its …
This review is primarily concerned with SIRT6. SIRT6 is a protein involved in the regulating chromatin and has been shown to have a number of roles in metabolism, aging, and disease. …
SIRT6 Widely Regulates Aging, Immunity, and Cancer - PMC
SIRT6 is a longevity protein that can inhibit the aging of cells, tissues, organs and the body by promoting DNA damage repair (5 – 7), maintaining normal chromosome structure (8 – 10), …
SIRT和AMPK靶点通路知识讲解 - 知乎 - 知乎专栏
sirt1和sirt2主要在细胞核和细胞质中表达；sirt3、sirt4、sirt5则主要定位于线粒体；sirt6、sirt7则位于细胞核和细胞核仁内。sirt蛋白家族共享一个nad+结合催化结构域，并且可能根据它们所涉 …