Since its discovery in 1978 and cloning in 1984, transforming growth factor-alpha (TGF α, TGFA) has been one of the most extensively studied EGF receptor (EGFR) ligands. In this review, we provide a historical perspective on TGFA-related studies, ...

Transforming growth factor alpha (TGFα) is perhaps the best studied member of the EGF family. It was initially identified in the conditioned media of sarcoma cells through its ability to promote a transformation of normal cultured cells.

2016年3月11日 · Transforming Growth Factor alpha (TGF-α) is a protein structurally similar to Epidermal Growth Factor (EGF) and a ligand for EGF-receptors, competing with Epidermal Growth Factors.

Transforming growth factor alpha (TGF alpha) is a 5.6 kd single-chain polypeptide that acts through binding to the epidermal growth factor receptor (EGFR). TGF alpha is produced in a wide range of normal as well as embryonic and neoplastic cells and tissues.

2024年12月25日 · TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

Transforming growth factor-α (TGFα) is an epidermal growth factor (EGF) superfamily member, and is produced by Sertoli, peritubular, and Leydig cells. From: Handbook of Cell Signaling (Second Edition), 2010

Transforming growth factor alpha (TGF alpha) is a 6 kDa polypeptide mitogen that interacts with the epidermal growth factor receptor and activates its intrinsic tyrosine kinase.

TGF alpha, like EGF, exerts its effect on cells through binding to the EGF-Receptor (EGF-R). Here we review the molecular and cell biology of TGF alpha before proceeding to describe our own work on signaling molecules induced in response to activation of the EGF-R.

TGFalpha is the physiologic human keratinocyte pro-motility factor in human serum autocrine TGF-alpha functions by facilitating re-entry into the cell cycle from sub-optimal growth states rather than promoting or controlling the proliferation of actively cycling cells.

Know comprehensive TGF-alpha protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.