2016年10月19日 · Here we show that the tumor suppressor p53 cooperates with Smad proteins, which are TGF-β signal transducers, to selectively activate plasminogen activator inhibitor type-1 (PAI-1) transcription....

Wild-type p53 and Smads physically interact and coordinately induce transcription of a number of key tumour suppressive genes. Conversely mutant p53 generally subverts tumour suppressive TGF-β responses, diminishing transcriptional activation of key TGF-β target genes.

2024年12月25日 · TGFA (Transforming Growth Factor Alpha) is a Protein Coding gene. Diseases associated with TGFA include Tooth Agenesis and Cleft Lip. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

本综述试图重新评估针对p53功能障碍性癌症所做的努力，即利用小分子恢复或增强癌细胞中野生型p53（wtp53）的活性，以及基于p53的免疫治疗策略和基于p53的基因治疗。

2016年10月19日 · Here we show that the tumor suppressor p53 cooperates with Smad proteins, which are TGF-β signal transducers, to selectively activate plasminogen activator inhibitor type-1 (PAI-1) transcription. p53 forms a complex with Smad2/3 in the PAI-1 promoter to recruit histone acetyltransferase CREB-binding protein (CBP) and enhance histone H3 ...

转录调节因子p53作为一种抑癌基因,可诱导细胞生长阻滞,凋亡,分化以及DNA修复.突变型p53丧失了野生型p53的正常功能,能促进细胞增殖转化而且具有致癌作用.TGF-β超家族信号通路广泛参与胚胎发育,细胞增殖,分化,迁移和凋亡,创伤修复.P53与TGF-β通路之间有着广泛的 ...

Wild-type p53 and Smads physically interact and coordinately induce transcription of a number of key tumour suppressive genes. Conversely mutant p53 generally subverts tumour suppressive TGF-β responses, diminishing transcriptional activation of key TGF-β target genes. Mutant p53 can also interact with Smads and this enables complex formation ...

2016年11月28日 · Crosstalk between transforming growth factor beta (TGF-β) signaling and p53 has a critical role in cancer progression. TGF-β signals via Smad and non-Smad pathways. Under normal conditions,...

2003年5月2日 · Here, we report that key cellular responses to TGF-beta signals rely on p53 family members. During Xenopus embryonic development, p53 promotes the activation of multiple TGF-beta target genes. Moreover, mesoderm differentiation is inhibited in p53-depleted embryos.

The p53 tumor suppressor is perhaps the most studied mediator of cellular senescence, and the p53 pathway is known to intersect with TGF-β signaling at several levels .