2020年9月30日 · Differentiation toward T-helper 1 (Th1) cells mediates inflammation and pathogen clearance, while T follicular helper (Tfh) cells facilitate germinal center (GC) reactions for the generation of...

Although chemokine (C-X-C motif) receptor 5-expressing T follicular helper (Tfh) cells are important in humoral immunity, their developmental regulation is unclear. Here we show that Tfh cells had a distinct gene expression profile and developed in vivo …

2024年6月4日 · Th1 and Th2 cells have been associated with the polarization of humoral responses. However, T follicular helper cells (Tfh) have a unique ability to access the B cell follicle and support the...

2011年12月12日 · Our data argue that Tfh and Th1 cells share a transitional stage through the signal mediated by STAT4, which promotes both phenotypes. However, T-bet represses Tfh cell functionalities, promoting full Th1 cell differentiation.

2012年1月25日 · Now, new evidence suggests that early during their development T H 1 cells pass through a T H 1–T FH cell stage, which involves a dynamic balance of signals mediated by the transcription...

Th1细胞的主要效应功能在于细胞免疫和炎症，包括活化其他免疫细胞如巨噬细胞、B细胞和CD8+ 细胞毒性T淋巴细胞（CTL）的细胞溶解和其他效应功能。 此外，Th1细胞在活化CD8+细胞毒性T细胞、促进其靶向杀伤肿瘤细胞中发挥重要作用。 Th1细胞表面标志物：CD3、CD4、CD28、CD44、CD45R、IFN-γR1以及CXCR3等。 Th1分泌的细胞因子：IFN-γ、TNFα、GM-CSF、IL-3、LT-α、LT-β、CXCR-3、CCL-2等。 表1.Th1细胞分泌的细胞因子及其功能.

There is no single event that defines Tfh cell differentiation, unlike Th1 cell differentiation for instance, which can be fully induced by interleukin-12 (IL-12) exposure in vitro or in vivo. Instead, Tfh cell differentiation is a multistep, multisignal process that also accommodates a significant amount of heterogeneity.

Genes up-regulated in CD4 SMARTA memory T cells: Th1 versus follicular helper (Tfh). Full description or abstract: CD4 T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for longlived antibody responses.

Tfh分化主要由IL-21介导，通过激活STAT3，作用于naïveT细胞，诱导其向Tfh分化。 IL-6和IL-27对于IL-21依赖的Tfh的分化发挥重要的调节作用。 BCL-6是Tfh细胞分化所必需的特异性转录因子。

2011年12月23日 · Although STAT4 can promote Tfh cell-like features, induction of T-bet inhibits Tfh cell genes and tips the balance toward a more Th1 cell-dominant phenotype. Our data indicate that early on after IL-12 stimulation, cells are uncommitted and complete differentiation reflects the counter-regulatory effects of STAT4 and T-bet.