Discover T helper type 17 (Th17) Cell Markers CD4, IL-6, and more with our interactive tool. Browse validated antibodies for Flow, IHC, ICC/IF, and WB+.

th17细胞的特征性转录因子为rorγt，分泌il-17a、il-17f、il-21、il-22和il-26。 Th17与多种自身免疫性疾病有关，如多发性硬化症、类风湿性关节炎，银屑病，炎症性肠病等。

在Th17细胞中，它可以以自分泌方式发挥作用，类似于IL-6的方式通过STAT3信号诱导RORγt表达，从而进一步增加Th17的分泌。 除了促进Th17反应，IL-21还通过增强Th1细胞、CD8 + 细胞毒性T细胞和NK细胞的功能来促进细胞免疫[ 20 ]。

2023年7月25日 · Th17细胞. Th17细胞通过分泌IL-17(包括IL-17A到IL-17F)、IL-21、IL-22、IL-26、TNF-α等多种细胞因子 参与固有免疫和某些炎症的发生，在免疫病理损伤，特别是自身免疫病的发生和发展中起重要作用。 图3.Th17细胞的分化及功能 （图片来源于Wu B , Zhang S …

The inherent plasticity and instability of these cells has made attempts to identify a single surface phenotyping marker for Th17 cells difficult, although some candidates have been suggested. CCR6, the chemokine receptor that drives cellular migration in response to CCL20, is expressed by Th17 cells and implicated in their recruitment to ...

In the present study, using transcriptomic profiling, we selected genes and analyzed the expression of these genes to find potential novel markers of Th17 lymphocytes. We found that APOD (apolipoprotein D); C1QL1 (complement component 1, Q subcomponent-like protein 1); and CTSL (cathepsin L) are expressed at significantly higher mRNA and ...

Th17 cells prevent severe HIV infection by maintaining the intestinal epithelial barrier during HIV infection in the gut. [30] Because of their high levels of CCR5 expression, the coreceptor for HIV, they are preferentially infected and depleted. [32] Thus, it is through Th17 cell depletion that microbial translocation occurs.

th17细胞是首个被确定有别于th1/th2模式的亚群，且基于il-23刺激后il-17a同型二聚体的表达。th17细胞生成另一个同型二聚体il-17家族成员il-17f，以及异质二聚体蛋白il-17af，il-17af由il-17a的一个亚基和il-17f的一个亚基组成。

2 天之前 · To profile T helper (Th) cell distribution after mitogen stimulation, established Th1 markers IFNγ, TNF, and IL-2; Th2 markers IL-4/5; and the Th17 marker, IL-17, are included. This optimized multicolor spectral flow panel allows a detailed immune-profiling of functional cytokines in the murine T cell compartment and might be useful for ...

2020年4月1日 · 【单细胞转录组】人类T细胞亚群分析Marker基因汇总 流式中文网 文献：Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing