2020年2月15日 · Thus, to our knowledge, we provide the first evidence that the expression of IL-3R on activated human Th cells is modulated by IL-4, and IL-3 regulates the effector functions of Th2 cells. Our results suggest that IL-3 may play an …

2024年6月12日 · Moreover, through its ability to induce a Th2 response, IL-3 protects during helminth infection but is detrimental during asthma, protozoan infections and pancreatic cancers. Assessment of plasma IL-3 levels may therefore serve as a prognostic marker to identify patients at risk of developing severe disease.

2020年2月15日 · The high GATA-3 expression and CCR4 + CRTH2 + cell number in the IL-3R + fraction suggest a relatively stable Th2 phenotype with the ability to produce Th2 cytokines. Thus, our results clearly demonstrate that IL-3R + Th cells belong to Th2 cell lineage.

Interleukin-3 (IL-3) is an important hematopoietic growth factor and immunregulatory cytokine. Although activated T helper cells represent a main source of IL-3, other cell types have been reported to express this cytokine. However, precise identification and quantification of the cells that produce IL-3 in vivo have not been performed.

In vivo, high TSLP is associated with the acquisition of a Th2eff phenotype in dLN, with down-regulation of Bcl6 and Il21 transcripts and up-regulation of Gata3, Il3, Il5, and Il13. These data suggest TSLP can act early during Th2 cell differentiation to support the development of …

2024年5月14日 · The function of GATA3 in lineage-specific gene expression through regulating the chromatin interaction network in Th2 cells is exemplified with Th2-specific Il3, Tnp2 loci, and Th1-specific Ccr7 locus (Figures S7 H and S7I).

2024年7月24日 · Th2 cell EVs prolong eosinophilia in vivo during allergic airway inflammation. Th2 cell EVs carry a potent form of the cytokine IL-3 on their surfaces, which inhibits apoptosis by activating Jak1/2-dependent pro-survival programs in eosinophils.

2008年1月15日 · Differentiation and function of eosinophils are regulated by the CD4 Th2 cytokines IL-3, IL-5, and GM-CSF, which all signal through a common beta receptor subunit (betac). Recent therapeutic approaches targeting IL-5 alone have not ablate …

2020年1月2日 · IL-3, a cytokine secreted by activated T lymphocytes, is known to regulate the proliferation, survival, and differentiation of hematopoietic cells. However, the role of IL-3 in regulation of T...

2006年1月16日 · In this review, we summarize recent reports regarding the transcription factors involved in Th2 differentiation and cell expansion, including Stat5, Gfi-1 and GATA-3. Stat5 activation is...

2021年4月1日 · IL-3 is the most important growth and activating factor for human and mouse basophils, primary effector cells of allergic disorders. IL-3-activated basophils and mast cells are also involved in different chronic inflammatory disorders, infections, and several types of cancer.

Moreover, through its ability to induce a Th2 response, IL-3 protects during helminth infection but is detrimental during asthma, protozoan infections and pancreatic cancers. Assessment of plasma IL-3 levels may therefore serve as a prognostic marker …

在免疫应答中，IL-3 通过调节巨噬细胞和树突状细胞的功能，增强抗原呈递和 T 细胞应答，同时调控 Th1/Th2 平衡，影响细胞免疫与体液免疫的协同作用。

Differentiation of naïve CD4 T cells into T helper (Th) 2 cells requires signaling through the T cell receptor and an appropriate cytokine environment. IL-4 is critical for such Th2 differentiation. We show that IL-2 plays a central role in this ...

2008年1月15日 · Th2 cytokines (e.g., IL-3, IL-4, IL-5, IL-9, IL-13, and GM-CSF) and eosinophils are thought to play critical roles in the induction of airway hyperreactivity (AHR) 3 and the development of lesions that underpin chronic airway wall remodeling .

2016年3月31日 · Here, we show that basophils expressing IL4 are enriched in tumor-draining lymph nodes (TDLN) of PDAC patients. Basophils present in TDLNs correlated significantly with the Th2/Th1 cell ratio in tumors, where they served as an independent prognostic biomarker of patient survival after surgery.

2018年12月1日 · IL-3 indirectly induces TH2 differentiation of naive T cells by inducing the release of IL-4 and retinoic acid from human basophils [29], [30], [31], [32], [33]. IL-3 was also shown to synergize with basophil-derived IL-4 and IL-13 to promote the …

IL-3 is the most important growth and activating factor for human and mouse basophils, primary effector cells of allergic disorders. IL-3-activated basophils and mast cells are also involved in different chronic inflammatory disorders, infections, and several types of cancer.

Via an assortment of different activation pathways, basophils produce cytokines such as IL-4 that promote Th2 differentiation. Furthermore, recent studies using different experimental systems have shown that basophils can act as antigen presenting cells both in vitro and in vivo .

4 天之前 · 1989年，Th1和Th2细胞的二分法奠定了T细胞研究的基石。然而，2005年，董晨教授与Casey Weaver团队在《自然·免疫学》上的突破性研究，揭示了第三类T细胞亚群——Th17细胞，其以分泌IL-17为标志，彻底改写了免疫学教科书。