2024年12月25日 · THBD (Thrombomodulin) is a Protein Coding gene. Diseases associated with THBD include Thrombophilia Due To Thrombomodulin Defect and Hemolytic Uremic Syndrome, Atypical 6. Among its related pathways are Diseases …

血栓调节蛋白（Thrombomodulin，TM）是使凝血酶由促凝转向抗凝的重要的血管内凝血抑制因子。 与凝血酶结合后可降低凝血酶的凝血活性，而加强其激活蛋白C的活性。

Thrombomodulin (TM), CD141 or BDCA-3 is an integral membrane protein expressed on the surface of endothelial cells and serves as a cofactor for thrombin. It reduces blood coagulation by converting thrombin to an anticoagulant enzyme from a procoagulant enzyme. [5]

这种结合导致蛋白 C 的激活，从而降解凝血因子 Va 和 VIIIa 并减少凝血酶的产生量。 该基因的突变是血栓栓塞性疾病的一个原因，也称为遗传性血栓形成倾向。 [RefSeq 提供，2008 年 7 月] The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds Thrombin.

TM up-regulated E-cadherin but down-regulated N-cadherin expression, resulting in reversal of epithelial-mesenchymal transition (EMT) in the lung cancer cells. High serum thrombomodulin expression is associated with non-alcoholic fatty liver disease. results do not suggest a predictive role for THBD c.1418C>T polymorphism in VTE recurrence

2022年1月5日 · 尽管几项研究已经在静脉血栓栓塞(vte)患者中发现了血栓调节蛋白基因(thbd)变异，但thbd在vte患者中的作用仍有待阐明。 近日，血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章，该研究旨在明确大型中老年人群中罕见和常见THBD变异 …

2022年1月5日 · 尽管几项研究已经在静脉血栓栓塞(vte)患者中发现了血栓调节蛋白基因(thbd)变异，但thbd在vte患者中的作用仍有待阐明。 近日，血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章，该研究旨在明确大型中老年人群中罕见和常见THBD变异 …

Acts upstream of or within female pregnancy. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; lung; and skeleton. Used to study thrombophilia.

2022年1月6日 · 尽管几项研究已经在静脉血栓栓塞(vte)患者中发现了血栓调节蛋白基因(thbd)变异，但thbd在vte患者中的作用仍有待阐明。 近日，血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章，该研究旨在明确大型中老年人群中罕见和常见THBD变异 …

The THBD 1418T allele is associated with lower soluble TM, both in plasma and in HUVEC-conditioned medium, and with an increase in functional membrane-bound TM in HUVEC, which could explain the increased activated protein C levels and the reduced VTE risk observed in individuals carrying this allele …