The Institute of Research Engineers and Scientists (The IRES) is a Registered Nonprofit International Scientific Society dedicated to the promotion of advance research in the field of Science, Engineering, and Social innovation at worldwide by organizing different international events in associations with various world class Universities ...

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An internal ribosome entry site, abbreviated IRES, is an RNA element that allows for translation initiation in a cap-independent manner, as part of the greater process of protein synthesis. Initiation of eukaryotic translation nearly always occurs at and is dependent on the 5' cap of mRNA molecules, where the translation initiation complex ...

内部核糖体进入位点（IRES）是天然存在于一系列mRNA中的翻译增强子，当 存在于目的基因之间时介导翻译的内部起始 （图2）。 因此，IRES可以通过设计类似于细菌操纵子的多顺反子表达盒，驱动由相同mRNA编码的几个基因的翻译。 处在IRES元件前后的两个基因相对独立,可以表达得到完整的目的蛋白。 但由于IRES的结构较大,其应用常受到载体容量的限制,并且IRES对位于 其后的基因翻译起始能力相对较弱。 Figure 2. Cap-dependent and internal ribosome entry site …

5 天之前 · Find here the Upcoming The IRES Conference 2025. IRES provides a premier international platform for bringing together researchers, engineers, and scientists to share their latest innovations and insights.

The IRESite database presents information about the experimentally studied IRES (Internal Ribosome Entry Site) segments. IRES regions are known to attract eukaryotic ribosomal translation initiation complex and thus promote translation initiation independently of the presence of the commonly utilized 5'-terminal 7mG cap structure.

2003年1月1日 · Internal Ribosome Entry Sites (IRES) are cis-acting RNA sequences able to mediate internal entry of the 40S ribosomal subunit on some eukaryotic and viral messenger RNAs upstream of a translation initiation codon. These sequences are very diverse and are present in a growing list of mRNAs.

2025年3月13日 · The first IRES in a cellular mRNA was discovered in the stress-induced chaperone BiP mRNA by its activity in translation initiation in poliovirus-infected cells when host translation is inhibited (Sarnow, 1989; Macejak and Sarnow, 1991). Many IRES-containing viral transcripts solely rely on their IRES for translation (Thompson, 2012b).

2019年7月30日 · IRESpy is a fast, reliable, high-throughput IRES online prediction tool. It provides a publicly available tool for all IRES researchers, and can be used in other genomics applications such as gene annotation and analysis of differential gene expression.

2020年4月1日 · Internal ribosome entry sites (IRESs) are functional RNA elements that can directly recruit ribosomes to an internal position of the mRNA in a cap-independent manner to initiate translation.