Thienamycin (also known as thienpenem) is one of the most potent naturally produced antibiotics known thus far, discovered in Streptomyces cattleya in 1976. Thienamycin has excellent activity against both Gram-positive and Gram-negative bacteria and …

Thienamycin, a new beta-lactam antibiotic, exhibited potent, broad-spectrum activity in vitro against gram-negative bacilli and gram-positive cocci, including many isolates resistant to currently available antibiotics.

Thienamycin | C11H16N2O4S | CID 441128 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

2024年10月28日 · Thienamycin, a potent β-lactam antibiotic, is notable for its ability to combat a wide range of bacterial infections. Discovered in the 1970s, it has been instrumental in the development of carbapenem antibiotics, often used as last-resort treatments for …

2012年2月3日 · Thienamycin is the most potent and broadest in spectrum of all antibiotics known today. Although a β-lactam, it is not a member of the penicillins or cephalosporins. It is active against aerobic and anaerobic bacteria, both Gram-positive and …

Beta-lactam antibiotics that differ from PENICILLINS in having the thiazolidine sulfur atom replaced by carbon, the sulfur then becoming the first atom in the side chain. They are unstable chemically, but have a very broad antibacterial spectrum.

A new beta-lactam antibiotic, named thienamycin, was discovered in culture broths of Streptomyces MA4297. The producing organism, subsequently determined to be a hitherto unrecognized species, is designated Streptomyces cattleya (NRRL 8057).

Thienamycin is a compound that has antibacterial activity, but lacks chemical stability. However, its stable derivative, N-formimidoyl thienamycin or imipenem, retains the antibacterial activity of the parent compound while also possessing the necessary chemical stability.

2010年1月22日 · We recently showed that ThnI, an LysR-type pathway-specific transcriptional activator, constitutes a key factor in controlling thienamycin biosynthesis.

Thienamycin, a natural product produced by Streptomyces cattleya is the first representative of a unique class of beta-lactam antibiotics, the carbapenems.