免疫调节达人之细胞因子— IL-4 - 知乎 - 知乎专栏
白细胞介素 4（IL-4）是主要由活化的 T 淋巴细胞、肥大细胞、嗜碱性粒细胞产生的一种多效性细胞因子。 1982 年 Howard 发现 T 细胞培养上清中有一种促进 B 细胞增殖的因子，起初命名为 …
The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8 - Nature
2024年9月25日 · Here we show that an interleukin-4 fusion protein (Fc–IL-4), a typical type 2 cytokine, directly acts on CD8 + T cells and enriches functional terminally exhausted CD8 + T …
Interleukin 4 - Wikipedia
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in …
白细胞介素-4 - 维基百科，自由的百科全书
白细胞介素-4 （白介素-4, Interleukin-4, IL-4）是II型 辅助T细胞 （Th2细胞）分泌的细胞因子。 白细胞介素-4的生物作用，包括刺激活化 B细胞 和 T细胞 增殖、 CD4+T细胞分化成II型辅助T细 …
白细胞介素4受体（IL-4R/IL-4Ra）：细胞因子多功能靶点，哮喘、 …
2024年3月29日 · 白细胞介素-4受体（IL-4R，又叫CD124；IL4Rα）是一种I型跨膜蛋白，属于白细胞介素家族成员之一。 IL4Rα链cDNA全长3.6 kb，含有一个编码825个氨基酸的开放阅读框 …
Recent advances in understanding the role of IL-4 signaling
Interleukin 4 (IL-4) was first identified as a factor that was produced by T cells and could enhance the proliferative response of B cells to anti-IgM and also was capable of inducible …
Regulation of IL4 gene expression by T cells and therapeutic
2003年7月1日 · Interleukin-4 (IL-4) is crucial for the differentiation of naive T helper (T H) cells into the T H 2 effector cells that promote humoral (antibody) immunity and provide protection...
Evolution and function of interleukin-4 receptor signaling in …
2020年3月6日 · IL-4 and IL-13 induce differentiation of naïve T cells to type 2 T helper and T follicular helper cells, B cell antibody production and isotype switching to immunoglobulin E …
白细胞介素-4 (IL-4) | 重组蛋白 | MCE - MCE-生物活性分子 ...
Interleukin-4 (IL-4) is a multipotent cytokine involved in the regulation of immune response. IL-4 is secreted mainly by mast cells, T cells, eosinophils and basophils, and is the receptor of IL-4 …
IL-4 drives exhaustion of CD8 + CART cells - PubMed
2024年9月12日 · Here, we investigate the regulation of CART cell exhaustion with three independent approaches including: a genome-wide CRISPR knockout screen using an in vitro …