Soluble Tim-3 serves as a tumor prognostic marker and …
2024年8月20日 · Resistance to PD-1 blockade in onco-immunotherapy greatly limits its clinical application. T cell immunoglobulin and mucin domain containing-3 (Tim-3), a promising …
火热的免疫检查点——TIM3靶点 - 知乎
TIM-3（T cell immunoglobulin domain and mucin domain-3） T 淋巴细胞免疫球蛋白黏蛋白 3，是一种活化诱导的抑制性分子，参与慢性病毒感染和癌症的免疫耐受和 T 细胞衰竭。 通过与 …
Tim-3: A co-receptor with diverse roles in T cell exhaustion and ...
2019年4月1日 · Tim-3 is characterized by 1) a conserved extracellular IgV domain with N-linked glycosylation sites, and a mucin-like stalk that contains O-linked glycosylation sites; 2) a …
Long non-coding RNA Lnc-Tim3 exacerbates CD8 T cell …
2018年4月30日 · Here, we show that Lnc-Tim3 is upregulated and negatively correlates with IFN-γ and IL-2 production in tumor-infiltrating CD8 T cells of HCC patients. Lnc-Tim3 plays a …
TIM-3 restrains anti-tumour immunity by regulating inflammasome ...
Here, using conditional knockouts of TIM-3 together with single-cell RNA sequencing, we demonstrate the singular importance of TIM-3 on dendritic cells (DCs), whereby loss of TIM-3 …
Targeted knockdown of Tim3 by short hairpin RNAs improves the function ...
This study was aimed to evaluate the effects of targeted-knockdown of Tim3 on the antitumor function of anti-mesothelin (MSLN)-CAR T cells. To knockdown Tim3 expression, three …
TIM3 Expression in Anaplastic-Thyroid-Cancer-Infiltrating …
Our studies show that TIM3 is a newly identified immune checkpoint in macrophages. Since TIM3 is known as a negative immune regulator, it should be considered as a promising …
Downregulation of TIM-3 mRNA expression in peripheral blood ... - PubMed
Our results suggest that below-normal expression of TIM-3 mRNA in PBMC may be involved in the pathogenesis of SLE. The T-cell immunoglobulin and mucin domain (TIM) family is …
Study on Tim3 Regulation of Multiple Myeloma Cell Proliferation
2020年11月19日 · We found that the relative mRNA and protein expression NF-κB signal pathway (PI3K, AKT, mTOR, NF-κB) decreased ( p <0.05) with down-regulation Tim3 of MM cells, …
膜型、可溶性Tim-3在抗肿瘤免疫应答中的作用及肿瘤基因治疗的 …
Tim-3 (T-cell immunoglobulin-and mucin-domain-containg molecule)分子的发现是源于寻找区分T_H1细胞和T_H2细胞的表面标志物.对其功能的研究揭示Tim-3在自身免疫性疾病和器官移植 …