TIMP3通过与血管内皮生长因子 (VEGF)受体2 直接交互发挥其抗血管生成效应和抑制增殖、迁移和管内皮细胞 (ECs)的形成。 在间质细胞中缺失将促进肿瘤生长和多器官转移（3-4)，其在肿瘤的侵袭、转移中发挥重要作用。 有文献报道表明：Timp-3的下调可以促使胶原蛋白I/III，结缔组织生长因子，转化生长因子β和下游Smad2/3通路。 2）TIMP-3也是炎症因子抑制剂，负性调控TACE (5),促使了TNF-a的释放增加（6）使机体发生炎症反应和血管重塑。 3.Timp-3与相关疾病. …

2024年12月25日 · TIMP3 (TIMP Metallopeptidase Inhibitor 3) is a Protein Coding gene. Diseases associated with TIMP3 include Sorsby Fundus Dystrophy and Fundus Dystrophy. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene. [5] [6] This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM).

2020年7月21日 · Among all proteins analyzed, we found that TIMP-3 bound to LRP-1 with the highest affinity. Furthermore, TIMP-3 was able to promote scavenging of its target enzymes, with...

由该基因家族编码的蛋白质是基质金属蛋白酶的抑制剂，基质金属蛋白酶是一组参与细胞外基质 (ECM) 降解的肽酶。 该基因的表达是响应有丝分裂刺激而诱导的，并且这种含有 netrin 结构域的蛋白质定位于 ECM。 该基因的突变与常染色体显性遗传病索斯比氏眼底营养不良有关。 [RefSeq 提供，2008 年 7 月] This gene belongs to the TIMP gene family.

Here, we provide an overview of TIMP3 gene structure, transcriptional and post-transcriptional regulators (transcription factors and microRNAs), protein structure and partners, its role in cardiovascular pathology and its application as therapy, while also drawing reference from TIMP3 function in other diseases.

2018年10月2日 · The secretome analysis showed that expression of TIMP-3 not only reduced shedding of several membrane proteins, but also induced an increase in levels of several soluble proteins, such as the...

2021年4月13日 · Altra’s Timp 3 Is Lightweight and Cushioned for Intense Trail Runs Don’t be afraid to go the distance in this amply cushioned, lightweight trail shoe. By Amanda Furrer Published: Apr 13, 2021 ...

Tissue inhibitor of metalloproteinases-3 (TIMP3) is vital in regulating several biological processes. TIMP3 exerts antitumour effects via matrix metalloproteinase (MMP)-dependent and MMP-independent pathways. Due to promoter methylation and miRNA binding, TIMP3 expression has been observed to decrease in various cancers.

TIMP-3 expression was associated with malignant behaviors of hepatocellular carcinoma, including portal vein invasion and lymph node metastasis. TIMP-3 expression was an independent prognostic factor for disease-free survival and overall survival