Titin is a large abundant protein of striated muscle. Titin's primary functions are to stabilize the thick filament, center it between the thin filaments, prevent overstretching of the sarcomere, and to recoil the sarcomere like a spring after it is stretched. [42]

肌联蛋白（英語： titin ，源自古希臘神話中的泰坦，形容其結構的巨大程度 [2] 。 又稱 connectin），又稱 肌巨蛋白 ，是 人体 中是由肌联蛋白基因（TTN）编码的 蛋白质 。

Titin (right) is shown in yellow, actin in blue, and myosin in red. Titin is the largest protein chain in your body, with more than 34,000 amino acids. This titanic protein acts like a big rubber band in our muscles. It is attached at one end to the Z-disk (shown here at the top in blue), which organizes the thin actin filaments.

Titin is a giant multi-functional sarcomeric filament that provides passive stiffness to cardiac myocytes. At its N-terminus, titin is embedded in the Z-disk of the sarcomere.

Titin, the largest protein in the human body, is well known as a molecular spring in muscle cells and scaffold protein aiding myofibrillar assembly. However, recent evidence has established another important role for titin: that of a regulatory node integrating, and perhaps coordinating, diverse signaling pathways, particularly in cardiomyocytes.

2022年5月2日 · Titin 1, also called connectin, is the largest known protein. It is found in the striated muscle tissue of humans and other vertebrates; homologous proteins exist in invertebrate animal families. Human titin is >1 µm long and consists of 244 folded protein domains. Adults’ bodies contain ≈500 g of titin.

2010年6月21日 · The giant protein titin is thought to play major roles in the assembly and function of muscle sarcomeres. Structural details, such as widths of Z- and M-lines and periodicities in the thick filaments, correlate with the substructure in the respective regions of the titin molecule.

Titin is a functionally pleiotropic protein with specific functions mediated by its unique regions. Proper sarcomere formation requires titin, as myosin uses it as a blueprint that determines the length of the thick filament (Tonino et al., 2017). Titin also contains spring-like domains that grant it …

Titin, a polypeptide chain protein that is greater than 1µm in length and 3-4 nm in width [2]. The protein molecule has a molecular weight of up to approximately 4 Mda. Titin is a multi-domain structure that which is found to be composed of two types of domains similar to immunoglobulin (Ig) and fibronectin. [3] .

Titin, also known as connectin, is an elastic and approximately 3,6 MDalton large protein which assembles itself to protein filaments. It is made of more than 30000 amino acids and includes 320 protein domains and therefore is known as the largest human protein. It is a part of the sarcomere, the smallest functional unit in the striated muscles.