Transketolase-like-1 (TKTL1) is a gene closely related to the transketolase gene (TKT).

Transketolase-like 1 (TKTL1) is a gene from the transketolase family that in fetal human neocortex is preferentially expressed in the two classes of neuroprogenitors, the apical progenitors in the ventricular zone and the basal progenitors in the subventricular zone.

2024年12月25日 · TKTL1 (Transketolase Like 1) is a Protein Coding gene. Diseases associated with TKTL1 include Wernicke-Korsakoff Syndrome and Wet Beriberi. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor and transketolase activity.

2022年9月9日 · Using overexpression in developing mouse and ferret neocortex, knockout in fetal human neocortical tissue, and genome-edited cerebral organoids, we found that the modern human variant, hTKTL1, but not the Neanderthal variant, increases the abundance of basal radial glia (bRG) but not that of intermediate progenitors (bIPs). bRG generate more neo...

在人类基因组中至今已经发现了1种转酮醇酶 (TKT)基因和2种TKT类似基因 (TKTL1和TKTL2)。 自从2005年Coy提出TKTL1基因和蛋白在恶性肿瘤中高表达后，人们便对TKTL1与肿瘤的关系进行了一系列基础和临床水平的研究。 尽管TKTL1在肿瘤发生、发展中的生化基础和作用方式仍未被充分阐述，但TKTL1的高表达确实对恶性肿瘤具有特异性的正向促进作用。 引用本文: 陆欢, 朱惠莉. TKTL1在恶性肿瘤中的研究进展 [J] . 肿瘤研究与临床, 2015, 27 (5) : 352-355. DOI: …

It is now clear that TKTL1 controls the cell cycle, is responsible for the development of cognitive abilities which enabled Homo sapiens to overtake Neanderthals, and is also accountable for dangerous cell proliferation in cancer. TKTL1 has become the focus of much research and is not likely to disappear any time soon.

2019年1月15日 · Three transketolase genes have been identified in the human genome to date: transketolase (TKT), transketolase-like 1 (TKTL1) and transketolase-like 2 (TKTL2). Altered TKT functionality is strongly implicated in the development of diabetes and various cancers, thus offering possible therapeutic utility.

2024年1月8日 · This article explains how you can add a ticketing arrangement (TK) element to a PNR. It will help you understand the difference between TKOK, TKTL and TKXL entries.

Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals. TKTL1 Knockdown Impairs Hypoxia-Induced Glucose-6-phosphate Dehydrogenase and Glyceraldehyde-3-phosphate Dehydrogenase Overexpression.

Transketolase (TKT) is an enzyme that is ubiquitously expressed in all living organisms and has been identified as an important regulator of cancer. Recent studies have shown that the TKT family includes the TKT gene and two TKT-like (TKTL) genes; TKTL1 and TKTL2.