TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3 recognizes double-stranded RNA in endosomes, which is a common feature of viral genomes internalised by macrophages and dendritic cells.

Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and chemokines, thereby collectively establishing an antiviral host response.

Gene ID: 7098, updated on 9-Feb-2025. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities.

2024年12月25日 · TLR3 (Toll Like Receptor 3) is a Protein Coding gene. Diseases associated with TLR3 include Immunodeficiency 83 Viral Infections and Human Immunodeficiency Virus Type 1. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll-Like receptor Signaling Pathways.

The Toll-like receptors (TLRs) 3, 7, 8 and 9 stimulate innate immune responses upon recognizing pathogen-derived nucleic acids. TLR3 is located on the cell surface and in cellular endosomes and recognizes double-stranded viral RNA or the synthetic mimic poly rI:rC.

2024年4月9日 · Cell surface TLRs (TLR1, TLR2, TLR4, and TLR5) recognize lipid and protein components, whereas endosomal TLRs (TLR3, TLR7, TLR8, TLR9, and TLR13) specialize in nucleic acid detection.

TLR3 is an intracellular recognition system that responds to viral nucleic acids (dsRNA, ssRNA and ssDNA containing unmethylated CpG motifs) as well as endogenous double-stranded RNA. A number of TLR3 agonists are described in the literature, such as RGC100, and ARNAX, a synthetic DNA–RNA hybrid compound [60, 61].

2019年12月31日 · Toll-like receptor 3 (TLR3) recognizes double-stranded RNA derived from virus and its synthetic analogue, polyinosinic–polycytidylic acid [poly (I:C)]. Upon poly (I:C) binding, TLR3...

TLR3 is an endosomal receptor with a well-demonstrated antiviral function in immune and epithelial cells. In recent years, this receptor has also been reported to be expressed in cancer cells and has been proposed as a marker of tumor progression in solid tumors.

2024年10月15日 · Inhibiting TLR3 or blocking exosome release reduces neuroinflammation and morphine tolerance, highlighting a potential therapeutic target for opioid tolerance management.