TLR3 is a member of the toll-like receptor family of pattern recognition receptors of the innate immune system. TLR3 recognizes double-stranded RNA in endosomes, which is a common …

Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs), proinflammatory cytokines, and chemokines, thereby collectively …

Gene ID: 7098, updated on 9-Feb-2025. The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and …

2024年12月25日 · TLR3 (Toll Like Receptor 3) is a Protein Coding gene. Diseases associated with TLR3 include Immunodeficiency 83 Viral Infections and Human Immunodeficiency Virus …

The Toll-like receptors (TLRs) 3, 7, 8 and 9 stimulate innate immune responses upon recognizing pathogen-derived nucleic acids. TLR3 is located on the cell surface and in cellular endosomes …

2024年4月9日 · Cell surface TLRs (TLR1, TLR2, TLR4, and TLR5) recognize lipid and protein components, whereas endosomal TLRs (TLR3, TLR7, TLR8, TLR9, and TLR13) specialize in …

TLR3 is an intracellular recognition system that responds to viral nucleic acids (dsRNA, ssRNA and ssDNA containing unmethylated CpG motifs) as well as endogenous double-stranded …

2019年12月31日 · Toll-like receptor 3 (TLR3) recognizes double-stranded RNA derived from virus and its synthetic analogue, polyinosinic–polycytidylic acid [poly (I:C)]. Upon poly (I:C) binding, …

TLR3 is an endosomal receptor with a well-demonstrated antiviral function in immune and epithelial cells. In recent years, this receptor has also been reported to be expressed in cancer …

2024年10月15日 · Inhibiting TLR3 or blocking exosome release reduces neuroinflammation and morphine tolerance, highlighting a potential therapeutic target for opioid tolerance management.