
Parkinson's disease-risk protein TMEM175 is a proton-activated …
2022年6月23日 · Here we show that TMEM175, a genetic risk factor for Parkinson's disease (PD), mediates the lysosomal H + leak by acting as a proton-activated, proton-selective channel on …
Cell:徐浩新/胡美钦/李平/王策等揭示帕金森病发病风险的新机 …
2022年6月23日,密歇根大学 徐浩新 团队(胡美钦 、 李平 、 王策 为共同第一作者)在 Cell 期刊发表了题为:Parkinson’s disease-risk protein TMEM175 is a proton-activated proton …
科学网—《细胞》:徐浩新团队首次揭秘溶酶体氢离子通道 - 小柯 …
北京时间2022年6月23日晚23时,在发表于 Cell 杂志的一项研究中,美国密歇根大学安娜堡分校 徐浩新(Haoxing Xu)团队 鉴定出首个溶酶体膜上的氢离子通道TMEM175,并发 …
Neurobiol Dis 综述丨南昌大学应俊/华福洲团队综述TMEM175与 …
近日,南昌大学第二附属医院应俊、华福洲团队在Neurobiology of Disease上发表了题为“TMEM175: A lysosomal ion channel associated with neurological diseases”的综述文章,总结 …
Nature︱一种由生长因子激活的溶酶体钾离子通道, 提示通道造孔 …
论文揭示了一种神经元溶酶体钾离子通道,该通道主要由造孔蛋白(pore-forming protein)TMEM175和 蛋白激酶B (即AKT)复合物组成。该研究也为理解造孔蛋白变异如何 …
TMEM175 Gene - GeneCards | TM175 Protein | TM175 Antibody
2024年12月25日 · TMEM175 (Transmembrane Protein 175) is a Protein Coding gene. Diseases associated with TMEM175 include Dementia, Lewy Body and Gaucher's Disease. Proton …
Transmembrane Protein 175, a Lysosomal Ion Channel Related to …
TMEM175 is a growth-factor-activated and AKT (protein kinase B)-gated lysosomal ion channel. It forms a complex with AKT and conformational changes in AKT are sufficient to activate …
TMEM175: A lysosomal ion channel associated with
2023年9月1日 · Transmembrane protein 175 (TMEM175), an ion channel in the lysosomal membrane that is essential for maintaining lysosomal acidity, has been proven to coordinate …
The lysosomal potassium channel TMEM175 adopts a novel
2017年7月19日 · Recently, the previously uncharacterized transmembrane protein 175 (TMEM175) was identified as the bona fide endosomal and lysosomal K + channel, whose …
Parkinson’s disease risk protein TMEM175 keeps lysosomes
2022年7月12日 · Hu et al. found that at a normal lysosomal pH (4.5–5.0), TMEM175 was about 10 5 times more permeable to protons than to potassium or sodium, and further identified a …