脑声常谈丨浅析系统性红斑狼疮(SLE)诱导模型 - 澎湃新闻
2024年11月25日 · 腹膜内注射降植烷（2,6,10,14-四甲基十五烷，或TMPD）是一种在矿物油中高浓度存在的类异戊二烯烷烃，是诱导系统性狼疮的标准方法，该系统性狼疮具有特征性器官受 …
E3 ligase FBXW7 aggravates TMPD-induced systemic lupus
2018年10月1日 · Our work revealed that FBXW7 expression in myeloid cells played a crucial role in TMPD-induced SLE progression in mice, which may provide novel ideas and theoretical …
王红艳组合作揭示AKT2通过抑制Ⅰ-IFN影响抗病毒感染和系统性红 …
2022年2月23日 · 通过检测来自病毒感染小鼠或tmpd诱导sle小鼠体内的巨噬细胞，以及临床sle病人的外周血单核细胞，研究人员均发现akt2表达下降。 敲除Akt2的小鼠通过升高Ifnb1的表 …
Induction of autoimmunity by pristane and other naturally …
2009年9月1日 · Tetramethylpentadecane (TMPD, or commonly known as pristane)-induced lupus is a murine model of systemic lupus erythematosus (SLE). Renal disease and autoantibody …
cGAS-STING 通路不会促进 SLE 小鼠模型的自身免疫,Frontiers in …
We found that both cGAS- and STING-deficiency not only failed to rescue mice from TMPD-induced SLE, but resulted in increased autoantibody production and higher proteinuria levels …
E3 ligase FBXW7 aggravates TMPD-induced systemic lupus
In the present study, we identified that FBXW7 is a crucial exacerbating factor for SLE development and progression in a mouse model induced by 2, 6, 10, 14 …
In the present study, we identified that FBXW7 is a crucial exacerbating factor for SLE development and progression in a mouse model induced by 2, 6, 10, 14 …
Deficiency of the type I interferon receptor protects mice from ...
Similar to its proposed role in human SLE, signaling via the IFNAR is central to the pathogenesis of autoantibodies and glomerulonephritis in TMPD-induced lupus. This lupus model is the first …
系统性红斑狼疮小鼠模型|BioMice百奥动物
系统性红斑狼疮(Systemic lupus erythematosus, SLE)是一种严重的自身免疫性疾病，其特征是免疫调节功能障碍，炎症细胞因子产生过多，自身反应性细胞和抗体 [1] 攻击正常组织(心脏、关 …
The Oxysterol Receptor EBI2 Links Innate and Adaptive Immunity …
2023年7月19日 · Next, we investigated how EBI2-deficient macrophages affect the development of SLE in vivo using TMPD-induced lupus model, which features the development of …