High TMTV at baseline was significantly associated with inferior PFS and OS in patients receiving either lenalidomide maintenance or placebo. Baseline TMTV combined with ECOG PS could improve risk stratification for patients who respond to R-CHOP induction, meeting an unmet need for early and better identification of ultra-risk DLBCL patients.

An initial pooled analysis of three prospective trials 4 including patients mainly treated with the R-CHOP regimen and without maintenance identified a superior 5-year progression-free survival (PFS) of 65% (95% CI 55.3-73.3) for patients with a low TMTV versus 33% (95% CI 20.0-46.1) for those with a high TMTV, independently from the end of ...

2 天之前 · PET/CT is performed at baseline, and 33 patients undergo mid-treatment scans after 40 Gy. Baseline ctDNA is detected in 71.0% of patients. Pre-treatment ctDNA concentration correlates with total metabolic tumor volume (TMTV) (p < 0.001) and total lesion glycolysis (TLG) (p = 0.001) but not treatment

2024年12月16日 · We aimed to explore the predictive value of total metabolic tumor volume (TMTV) and beta-2-microglobulin (B2M) levels in patients with follicular lymphoma (FL) with a high tumor burden receiving standard first-line immunochemotherapy.

New volume-based parameters derived from baseline 18 F-FDG PET/CT, such as total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG), can reflect metabolic volume and activity and have been proposed as quantitative indexes of tumor metabolism biomarkers in Hodgkin’s and B-cell lymphomas [8].

2020年4月16日 · TMTV was computed on baseline positron emission tomography/computed tomography using the 41% maximum standardized uptake value method; the optimal TMTV cutoff for progression-free (PFS) and overall survival (OS) was determined and confirmed by a training validation method.

2020年7月23日 · 通过PRT-CT扫描并应用41%的最大标准化摄取值阈值法计算出的总肿瘤代谢体积（TMTV）可以评估肿瘤负荷，并且已经证实与霍奇金淋巴瘤，滤泡性淋巴瘤和未治疗的DLBCL的预后相关。 本研究通过对REMARC临床试验（NCT01122472）来评估基线TMTV是否对R-CHOP治疗有效的老年患者是否具有预后价值。 方法. 在REMARC临床试验中，经过6或8个周期的标准R-CHOP治疗后获得CR或PR的650名60-80岁老年DLBCL患者被随机分配1：1分别给予 …

2024年11月5日 · Total metabolic tumor volume (TMTV) derived from positron emission tomography/computed tomography (PET/CT) data has been shown to serve as an accurate tumor burden surrogate and be associated with outcomes in FL (Cottereau et al. Ann Oncol 2024).

2016年10月9日 · 法国研究者Michel Meignan等报告，在滤泡 淋巴瘤 (FL)患者中，基线肿瘤代谢总体积 (TMTV)是一个较好的独立预后因素。 同滤泡性 淋巴瘤 国际预后指数2 (FLIPI2)评分结合，能作为疾病早期进展的识别标志。 对于根据PET结果调整一线治疗方案的患者而言，基线TMTV的意义需被进一步评估。 (J Clin Oncol. 2016年8月22日在线版) 在高肿瘤负荷的FL患者中，当前的预后模型在鉴别疾病进展高危患者方面和早期死亡方面的结果无法令人满意。 该项汇总分析自三 …

2024年9月3日 · Total metabolic tumor volume (TMTV) is prognostic in lymphoma. However, cutoff values for risk stratification vary markedly, according to the tumor delineation method used. We aimed to create a standardized TMTV benchmark dataset allowing TMTV to be tested and applied as a reproducible biomarker.