2024年12月25日 · TNIP2 (TNFAIP3 Interacting Protein 2) is a Protein Coding gene. Diseases associated with TNIP2 include Esophagus Sarcoma and Thrombocytopenia. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and MAP kinase activation.

Several components of the NF-κB signaling pathway have been reported to interact with the protein TNIP2 (also known as ABIN2), and TNIP2 can both positively and negatively regulate NF-κB- dependent transcription of target genes.

TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene. [ 5 ] [ 6 ] [ 7 ] TNIP2 contains multiple amino acid sites that are phosphorylated and ubiquitinated . [ 8 ]

2025年2月9日 · Long noncoding RNA NAV2-AS5 relieves chondrocyte inflammation by targeting miR-8082/TNIP2 in osteoarthritis. TNIP2 mediates GRbeta-promoted inflammation and is associated with severity of major depressive disorder.

2025年1月4日 · Title: TNIP2 mediates GRβ-promoted inflammation and is associated with severity of major depressive disorder. The increased inflammation of Map3k8(-/-) mice in allergic airway inflammation and colitis results from reduced …

Several components of the NF-κB signaling pathway have been reported to interact with the protein TNIP2 (also known as ABIN2), and TNIP2 can both positively and negatively regulate NF-κB- dependent transcription of target genes.

该基因编码一种蛋白质，可作为 NFkappaB 激活的抑制剂。 编码的蛋白质还参与特定细胞类型的 MAP/ ERK 信号通路。 它可能参与内皮细胞的凋亡。 可变剪接导致多个转录本变体。 与该基因相关的假基因位于 X 染色体上。 [RefSeq 提供，2014 年 5 月] This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ ERK signaling pathway in specific cell types.

2023年6月21日 · TNFAIP3-interacting protein 2 (TNIP2) is known as a negative regulator of NF-κB signaling and inhibit inflammatory response and apoptosis, and is also involved in RNA metabolism. In this study, we investigated the potential role of TNIP2 in amyloidogenesis critically associated with Alzheimer’s disease (AD).

2024年10月14日 · TNIP2重组蛋白的基本信息. 蛋白名称: TNIP2重组蛋白. 分子量: 大约为35-45 kDa。 结构特征: TNIP2蛋白含有多种功能域，包括参与蛋白-蛋白相互作用的UBAN（Ubiquitin Binding in ABIN and NEMO） 功能域，它能够与泛素链结合，在NF-κB信号传导调控中发挥作用。 …

2023年4月23日 · TNFAIP3-interacting protein 2 (TNIP2) is known as a negative regulator of NF-κB signaling and inhibit inflammatory response and apoptosis, and is also involved in RNA metabolism. In this study, we investigated the potential role of TNIP2 in amyloidogenesis critically associated with Alzheimer's dise …