Nuclear respiratory factor-1 (NRF-1) and hypoxia-inducible factor (HIF)-1α are transcriptional regulatory elements implicated in multiple biological functions, including oxidative...

TOMM20 is a subunit of the outer mitochondrial membrane translocase that plays a major role as a receptor of precursor proteins with N-terminal cleavable presequences targeted to the …

2021年8月1日 · Transcription factor peroxisome proliferator-activated receptor gamma coactivator-1-alpha (PGC-1α) is considered to contribute to the increase of mtDNAcn, together …

2021年9月6日 · Genetic deletion of Nrf1 prevented regenerating cardiomyocytes from activating a transcriptional program required for heart regeneration. Conversely, Nrf1 overexpression …

2024年9月23日 · Molecular biology experiments have demonstrated that SA intervention further inhibits the phosphorylation of FUNDC1 at Tyr18 and downregulates TOM20 expression. SA …

2022年10月9日 · 近日，重庆大学附属江津医院张义国教授团队在 Redox Biology 期刊发表了题为：Nrf1 is an indispensable redox-determining factor for mitochondrial homeostasis by …

2010年12月20日 · The N-terminal Tom20-binding element evidently promotes efficient binding of the presequence to Tom20 at the cis site of the TOM40 complex. Besides, the second Tom20 …

为了探索tom转位酶复合体的组装机制，研究团队另辟蹊径，利用哺乳动物细胞重组表达系统重构了该组装过程，并实现精准控制，人为为组装按下“暂停键”（图1）。

We set out to test this dynamic model by determining the mobility of the receptor subunit Tom20 in the OMM in situ in mammalian cells. Previously, we found that at least two subpopulations …

Here we investigated the associa-tion of the receptor Tom20 with the TOM complex. Tom20 was found in the TOM complex, but not in a smaller subcomplex. In addition, a subcomplex was …