TOPBP1 - Wikipedia
TOPBP1 primarily regulates the DNA damage repair response through its ability to activate the damage response kinase, ataxia-telangiectasia mutated and RAD3-related (ATR). It also plays …
TOPBP1 Gene - GeneCards | TOPB1 Protein | TOPB1 Antibody
2024年12月25日 · TOPBP1 (DNA Topoisomerase II Binding Protein 1) is a Protein Coding gene. Diseases associated with TOPBP1 include Byssinosis and Ataxia-Telangiectasia. Among its …
DNA损伤反应与DNA的修复（三） - 知乎专栏
TopBP1（DNA topoisomerase 2 binding protein 1）具有刺激ATR激酶活性的ATR激活域，激活域的失活突变对哺乳动物细胞是致命的。 另一种ATR激活蛋白 ETAA1 含有与TopBP1类似 …
TOPBP1 DNA topoisomerase II binding protein 1 [ (human)]
2025年2月9日 · TopBP1 is likely to be involved in hereditary predisposition to breast and/or ovarian cancer; findings show TopBP1 interacts with p53 hot spot mutants and NF-YA and …
TopBP1: A BRCT-scaffold protein functioning in multiple cellular ...
Human TopBP1 contains nine BRCT domains and functions in DNA replication initiation, checkpoint signalling, DNA repair and influences transcriptional control. TopBP1 and its …
DNA 拓扑异构酶 II 结合蛋白 1（TOPBP1）基因 | MCE
该基因编码与拓扑异构酶 II β 的 C 末端区域相互作用的结合蛋白。 这种相互作用表明这种蛋白质通过 DNA 链的瞬时断裂在拓扑异构酶 II β 的催化反应中起支持作用。 [RefSeq 提供，2008 …
A small-molecule inhibitor of TopBP1 exerts anti-MYC activity and ...
2023年10月31日 · Based on this, we conducted a large-scale molecular docking screening to identify a small-molecule inhibitor that specifically targets the BRCT7/8 domains of TopBP1, …
TopBP1: A BRCT-scaffold protein functioning in multiple cellular ...
2014年10月1日 · TopBP1 and homologues (TopBP1-family) are all ‘scaffold’ or ‘hub’ proteins that are able to make numerous protein–protein interactions through their constituent BRCT …
TOPBP1 as a potential predictive biomarker for enhanced …
2025年2月7日 · DNA topoisomerase II-binding protein 1 (TOPBP1) plays a supportive role in regulating the DDR pathway, and its overexpression has been linked to the tumorigenesis of …
TOPBP1 regulates RAD51 phosphorylation and chromatin loading …
2016年2月1日 · We show that TOPBP1 acts in homologous recombination (HR) repair, impacts olaparib response, and exhibits aberrant patterns in subsets of human ovarian carcinomas. …