2011年4月14日 · Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–Barr virus (EBV) infection, and has since emerged as the crucial regulator of...

2025年2月24日 · Single-cell RNA-seq analysis identifies IRF7 as a pivotal mediator in the spleen-heart communication network that is initially induced in the spleen and orchestrates functional changes in...

2023年8月9日 · Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor that produced IFN-I and regulated innate immune response, subsequent studies have revealed that IRF7 performs a multifaceted and versatile functions in multiple biological processes.

2024年12月25日 · IRF7 (Interferon Regulatory Factor 7) is a Protein Coding gene. Diseases associated with IRF7 include Immunodeficiency 39 and Primary Immunodeficiency With Predisposition To Severe Viral Infection. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and SARS-CoV-2 Infection.

2005年3月30日 · Using mice deficient in the Irf7 gene (Irf7-/- mice), we show that the transcription factor IRF-7 is essential for the induction of IFN-α/β genes via the virus-activated, MyD88-independent...

2023年5月11日 · Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs) family, is located downstream of the pattern recognition receptors (PRRs)-mediated signaling pathway and is essential for the production of type I interferon (IFN-I).

We demonstrate that transcriptional repression of IRF7 by MYC provides an additional layer of tight regulation of IRF7 that ensures the appropriate level of type I IFN production and prevents the development of autoimmune disease. Combination studies have identified the IRF7 gene as a critical target of MYC, although not its only target.

干扰素调节因子（IRF）7最初被认为是产生IFN-I并调节先天免疫反应的主要转录因子，随后的研究表明IRF7在多种生物过程中发挥多方面和多功能的功能。 在这篇综述中，我们全面概述了 IRF7 在免疫和自身免疫中的作用的当前知识。 我们重点关注IRF7在IFN-I中的最新调控机制，包括信号通路、转录、翻译和翻译后水平、二聚化和核转位，以及IRF7在IFN-III和COVID-19中的作用。 除了抗病毒免疫之外，我们还讨论了IRF7在自身免疫中的作用和机制，进一步的研究将扩大我们 …

2024年6月17日 · This gene encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. It has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue.

We found as with previous experiments, the priming of Poly I:C induced significant enhancement of total IRF7, while neither LPS nor Pam3Csk4 priming had any notable effect on IRF7 production (Fig 5). In addition, none of the agonists induced any detectable changes in IRF3, neither TLR2 nor TLR4 ( Fig S4 ).