Toll样受体 (TLRs)作为连接天然免疫和获得性免疫的桥梁,其介导的信号转导通路及其作用一直是人们研究的焦点.由髓样分化因子88 ( myeloid differentiation primary response protein 88,MyD88)承接的转导途径称为MyD88依赖途径,是几乎所有TLRs信号转导的共同通路 (TRL3除外),由β干扰素TIR结构域衔接蛋白 (TIR-domain-containing adaptor inducing interferon-β,TRIF)联接的信号通路被称为Myd88非依赖途径,主要存在于TLR3和TLR4通路中,TLR3可以直接绑定TRIF,TLR4则 …

At TRI, our vision is for a rural India where everyone has equal opportunities to thrive. By prioritizing communities and leveraging innovations in public and private systems, we aim to nurture flourishing localities with grounded solutions for sustainable and scalable change.

trif则主要介导tlr3和tlr4的信号。被tram募集至tlr4或直接与tlr3结合后，一方面trif与traf6及traf3相互作用，通过rip-1激酶激活tak1以活化nf-κb和mapk信号通路；另一方面，traf3募集ikk家族的tbk1和ikki激酶，磷酸化修饰转录因子irf3使其活化二聚入核诱导表达一型干扰素基因。

TIR domain containing adaptor molecule 1 (TICAM1; formerly known as TIR-domain-containing adapter-inducing interferon-β or TRIF) is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. [5]

TIR 结构域含有接头蛋白如 TIRAP、TRIF 和 TRAM，此结构域可为单个 TLR 信号转导级联提供特异性，从而调控 TLR 介导的信号转导通路。 TRAF3 通过自身降解，对依赖于 MyD88 和依赖于 TRIF 的信号转导调节具有非常重要的作用，分别可激活依赖于 MyD88 的信号转导和抑制依赖于 TRIF 的信号转导 (反之亦然)。 Barton GM, Kagan JC (2009) A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat. Rev. Immunol. 9 (8), 535–42.

2019年9月11日 · TIR domain-containing adaptor inducing interferon-β (TRIF) is an essential adaptor protein required for innate immune responses mediated by Toll-like receptor (TLR) 3- and TLR4....

trif招募traf6并激活tak1以激活nf-κb，很可能是通过泛素化依赖的机制，类似于myd88依赖的途径。 TRIF还通过独特的RIP同型相互作用基序招募适配器RIP1。 在TLR3激动剂的刺激下，RIP1经历了K63连锁的多泛素化，这一修饰是NF-κB激活所必需的。

TRIF, or TIR-domain-containing adapter-inducing interferon-β, is an adapter protein in microglial cells that is activated in response to the binding of fibrillar amyloid-β with TLR4, leading to the activation of the TRIF-dependent signaling pathway involved in …

Toll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF)-dependent signaling is required for TLR-mediated production of type-I IFN and several other proinflammatory mediators. Various pathogens target the signaling molecules and transcriptional regulators acting in the TRIF pathway, thus demonstra …

2013年10月16日 · 小鼠的信号转导障碍并不和trif敲除小鼠完全一致.trif 同时表达于胞膜和胞内体,但目前研究表明TRIF介导的信号 转导发生在胞内,其相关动力学机制还有待进一步阐明.