
信号分子TRIF的研究进展 - 百度学术
Toll样受体 (TLRs)作为连接天然免疫和获得性免疫的桥梁,其介导的信号转导通路及其作用一直是人们研究的焦点.由髓样分化因子88 ( myeloid differentiation primary response protein 88,MyD88)承接的转导途径称为MyD88依赖途径,是几乎所有TLRs信号转导的共同通路 (TRL3除外),由β干扰素TIR结构域衔接蛋白 (TIR-domain-containing adaptor inducing interferon-β,TRIF)联接的信号通路被称为Myd88非依赖途径,主要存在于TLR3和TLR4通路中,TLR3可以直接绑定TRIF,TLR4则 …
TRIF
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天然免疫系统中的模式识别受体 - 知乎 - 知乎专栏
trif则主要介导tlr3和tlr4的信号。被tram募集至tlr4或直接与tlr3结合后,一方面trif与traf6及traf3相互作用,通过rip-1激酶激活tak1以活化nf-κb和mapk信号通路;另一方面,traf3募集ikk家族的tbk1和ikki激酶,磷酸化修饰转录因子irf3使其活化二聚入核诱导表达一型干扰素基因。
TICAM1 - Wikipedia
TIR domain containing adaptor molecule 1 (TICAM1; formerly known as TIR-domain-containing adapter-inducing interferon-β or TRIF) is an adapter in responding to activation of toll-like receptors (TLRs). It mediates the rather delayed cascade of two TLR-associated signaling cascades, where the other one is dependent upon a MyD88 adapter. [5]
Toll 样受体信号转导 | Cell Signaling Technology
TIR 结构域含有接头蛋白如 TIRAP、TRIF 和 TRAM,此结构域可为单个 TLR 信号转导级联提供特异性,从而调控 TLR 介导的信号转导通路。 TRAF3 通过自身降解,对依赖于 MyD88 和依赖于 TRIF 的信号转导调节具有非常重要的作用,分别可激活依赖于 MyD88 的信号转导和抑制依赖于 TRIF 的信号转导 (反之亦然)。 Barton GM, Kagan JC (2009) A cell biological view of Toll-like receptor function: regulation through compartmentalization. Nat. Rev. Immunol. 9 (8), 535–42.
Regulation of TRIF-mediated innate immune response by K27 …
2019年9月11日 · TIR domain-containing adaptor inducing interferon-β (TRIF) is an essential adaptor protein required for innate immune responses mediated by Toll-like receptor (TLR) 3- and TLR4....
一文带你完全了解Toll样受体(二)——通路 - 丁香园论坛
trif招募traf6并激活tak1以激活nf-κb,很可能是通过泛素化依赖的机制,类似于myd88依赖的途径。 TRIF还通过独特的RIP同型相互作用基序招募适配器RIP1。 在TLR3激动剂的刺激下,RIP1经历了K63连锁的多泛素化,这一修饰是NF-κB激活所必需的。
TRIF - an overview | ScienceDirect Topics
TRIF, or TIR-domain-containing adapter-inducing interferon-β, is an adapter protein in microglial cells that is activated in response to the binding of fibrillar amyloid-β with TLR4, leading to the activation of the TRIF-dependent signaling pathway involved in …
TRIF-dependent TLR signaling, its functions in host defense and ...
Toll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF)-dependent signaling is required for TLR-mediated production of type-I IFN and several other proinflammatory mediators. Various pathogens target the signaling molecules and transcriptional regulators acting in the TRIF pathway, thus demonstra …
【doc】信号分子TRIF的研究进展 - 豆丁网
2013年10月16日 · 小鼠的信号转导障碍并不和trif敲除小鼠完全一致.trif 同时表达于胞膜和胞内体,但目前研究表明TRIF介导的信号 转导发生在胞内,其相关动力学机制还有待进一步阐明.