Taken together, our data suggest that the suppression of TRIF and TBK1, which mediates transcriptional activation of NF-kappaB, AP-1, and IRF-3, contributes to resveratrol's broad-spectrum inhibitory activity, and that this compound can be further developed as a lead anti-inflammatory compound.

2019年9月11日 · TIR domain-containing adaptor inducing interferon-β (TRIF) is an essential adaptor protein required for innate immune responses mediated by Toll-like receptor (TLR) 3- and TLR4. Here we...

2015年1月29日 · These signals activate the protein kinase TBK1 and the transcription factor IRF3, which tells cells to secrete interferon proteins (IFNs) important for host defense. Liu et al. now report a common signaling mechanism used by all three types of innate immune receptor-adaptor protein pairs to activate IRF3 and generate IFNs.

2015年3月13日 · Phosphorylated MAVS and STING then bind to a positively charged surface of interferon regulatory factor 3 (IRF3) and thereby recruit IRF3 for its phosphorylation and activation by TBK1. We further show that TRIF, an adaptor protein in Toll-like receptor signaling, activates IRF3 through a similar phosphorylation-dependent mechanism.

TRIF 能够作用于两种蛋白质——IKKε-TBK1（TBK1就是端锚蛋白结合激酶1，在干扰素一节中，我们曾略有提到）和受体互作蛋白1(receptor-interacting protein 1)。IKKε-TBK1能激活IRF3（就是干扰素调节因子3），IRF3再进入细胞核去刺激干扰素刺激反应元件(interferon-stimulated response ...

2016年9月16日 · TANK结合激酶1（TBK1）是Ⅰ型干扰素合成过程中最为关键的蛋白激酶，在抗病毒固有免疫应答中发挥重要的作用。 TBK1可以被RIG-I-MAVS、cGAS-STING和TLR3/4-TRIF抗病毒信号通路所活化，作为重要的节点蛋白，其活化受到磷酸化、泛素化、SUMO化等一系列机制复杂而精密的调控。 本文对TBK1在抗病毒免疫应答中的作用及其调控机制的研究进展进行综述。 The innate immune response against viral infection is mainly relies on type I interferon, the …

2006年12月1日 · IFN-β and TNF-α reporter gene expression assay demonstrated that SHP-2 deficiency significantly increased TRIF- and TBK1-activated gene expression. These results suggested that SHP-2 inhibits poly(I:C)-induced proinflammatory cytokine and type I IFN expression at least partially through TRIF- and TBK1-dependent pathway.

2025年3月6日 · TBK1 and IKKε act as noncanonical IKKs downstream of TLRs and RLRs. Upon activation, TLRs recruit adaptor proteins, including TRIF and TRAF3, which activate TBK1 within a complex comprising its adapters NAP1, SINTBAD, TANK, and OPTN. Activated TBK1 and IKKε phosphorylate transcription factors like IRF-3, promoting their nuclear translocation.

Toll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF), tumor necrosis factor receptor-associated factor 6 (TRAF6) and TANK-binding kinase 1 (TBK1) are critical signal transducers in toll-like receptors (TLRs) signaling pathway. In the present study, TRIF, TRAF6 and TBK1 were characterized from …

2003年4月14日 · Here we report that the noncanonical IκB kinase homologs, IκB kinase-ε (IKKε) and TANK-binding kinase-1 (TBK1), which were previously implicated in NF-κB activation, are also essential components...