2024年12月25日 · TRIM24 (Tripartite Motif Containing 24) is a Protein Coding gene. Diseases associated with TRIM24 include Differentiated Thyroid Carcinoma and Aortic Malignant Tumor. Among its related pathways are FGFR1 mutant receptor …

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene. [5][6][7]

2017年11月13日 · TRIpartite Motif-containing protein 24 (TRIM24), also known as Transcription Intermediary Factor 1 alpha (TIF1α) is a reader of non-canonical histone signature H3K23ac 8.

2022年7月8日 · Here we show that the E3-ligase TRIM24 is a critical factor linking insulin signalling to P-bodies. Upon insulin stimulation, protein kinase B (PKB, also known as Akt) phosphorylates TRIM24 and...

TRIM24 regulate resistance to Gefitinib via Akt pathway in non-small cell lung cancer cells. TRIM24 is overexpressed in human bladder cancer and facilitates bladder cancer growth and invasion, possibly through NF-kappaB and AKT signaling pathways. functions as an oncogene in colorectal carcinogenesis

trim24作为视黄酸信号调节因子被识别,trim24可利用视黄酸（ra）转录来控制肿瘤的发生，trim24的c末端可结合到pik3ca基因位点，促进pik3ca的转录，提高pi3k转导能力，而pi3k可反向作用于trim24，同时抑制抑癌基因p27的作用，从而促进了肿瘤的生长促进了肿瘤的生长[4]。

Tripartite motif-containing 24 (TRIM24), also known as transcriptional intermediary factor 1α (TIF1α), is the founding member of TIF1 family. Recent evidence indicates that aberrant expression of TRIM24, functions as an oncogene, is associated with poor prognosis across various cancer types.

2016年6月13日 · We show that recurrent PC-driver mutations in speckle-type POZ protein (SPOP) stabilize the TRIM24 protein, which promotes proliferation under low androgen conditions. TRIM24 augments AR signaling, and AR and TRIM24 co-activated genes are significantly upregulated in CRPC.

2017年11月13日 · Here, we determine that non-canonical histone signature acetylated H3 lysine 23 (H3K23ac)-binding protein tripartite motif-containing 24 (TRIM24) is upregulated in clinical GBM specimens and required for EGFR-driven tumorigenesis.

TRIM 基序包括三个锌结合域——一个 RING、一个 B-box 类型 1 和一个 B-box 类型 2——以及一个卷曲螺旋区域。 已针对该基因描述了编码不同同种型的两种可变剪接转录物变体。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors.