2015年9月15日 · We demonstrate the role of molecular switching of TrkA/p75 NTR signaling cascade in organophosphate pesticide-Monocrotophos (MCP) induced neurotoxicity in stem cell derived cholinergic neurons...

The p75 ICD –TrkA (or c29–TrkA) active complex binds NGF through high-affinity ECD sites. Allosteric modulation to the Trk ECD may (i) improve ligand access to D5, (ii) position D1 and D4 appropriately to promote ligand-D5 interaction, and/or (iii) reveal a second NGF-binding site.

We demonstrate clearly for the first time that p75 NTR –TrkA binding induces the transcytosis of p75 NTR at the basolateral side, showing that TrkA drives the endocytic trafficking of p75 NTR, leading to a change in its topology in the cell.

Thirty years ago, it was discovered that p75 neurotrophin receptor and tropomyosin receptor kinase A form a complex and mediate high-affinity ligand binding and survival signaling; however, despite decades of functional and structural research, the mechanism of modulation that yields this high-affinity complex remains unclear.

2007年1月4日 · Nerve growth factor engages two structurally distinct transmembrane receptors, TrkA and p75, which have been proposed to create a “high-affinity” NGF binding site through formation of a ternary TrkA/NGF/p75 complex.

2006年9月20日 · Nerve growth factor engages two structurally distinct transmembrane receptors, TrkA and p75, which have been proposed to create a "high-affinity" NGF binding site through formation of a ternary TrkA/NGF/p75 complex.

Remarkably, TrkA rescues from cell death by a mechanism involving the endocytosis of p75CTF. These results suggest that the inhibition of γ-secretase activity in aged patients, where the expression of TrkA in the BFCNs is already reduced, could accelerate cholinergic dysfunction and promote neurodegeneration.

2018年1月1日 · In this study, the neurotrophin tyrosine receptor kinase TrkA (also called NTRK1), the common neurotrophin receptor p75NTR, and the proneurotrophin receptor sortilin were analyzed with immunohistochemistry in a cohort of thyroid cancers (n = 128) and compared with adenomas and normal thyroid tissues (n = 62).

2021年7月1日 · The neurotrophin receptors p75 and tyrosine protein kinase receptor A (TrkA) play important roles in the development and survival of the nervous system. Biochemical data suggest that p75 and TrkA reciprocally regulate the activities of each other.

Biochemical data suggest that p75 and TrkA reciprocally regulate the activities of each other. For instance, p75 is able to regulate the response of TrkA to lower concentrations of nerve growth factor (NGF), and TrkA promotes shedding of the extracellular domain of p75 by α-secretases in a ligand-dependent manner.