Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival. It has stem cell-like qualities.

Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1) [5] is a protein that in humans is encoded by the TACSTD2 gene. [6] [7] [8] This intronless gene is located at the short arm of chromosome 1 (1p32.1). [9] It encodes a carcinoma-associated antigen defined by the monoclonal ...

Trophoblast cell surface antigen-2 (Trop-2) is a glycoprotein that was first described as a membrane marker of trophoblast cells and was associated with regenerative abilities. Trop-2 overexpression was also described in several tumour types.

Trop-2 (also called epithelial glycoprotein-1, gastrointestinal antigen 733-1, membrane component surface marker-1, and tumor-associated calcium signal transducer-2), is a product of the TACSTD2 gene located at 1p32.1 reviewed in Goldenberg et al. [1].

2023年7月1日 · Trophoblast surface antigen 2 (Trop-2) is a type I transmembrane glycoprotein involved in Ca 2+ signaling in tumor cells. It is highly expressed in various tumor tissues than in normal tissues and represents a novel and promising molecular target for caner targeted therapy.

Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival. It has stem cell-like qualities.

2022年2月25日 · This article provides an overview of antibody-drug conjugates for the treatment of solid tumors and examines emerging evidence demonstrating Trop-2 as a potential target in breast and lung...

2024年4月23日 · Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 antibody named...

2022年2月1日 · Trophoblast cell-surface antigen-2 (Trop-2) was originally described in trophoblasts and fetal tissues, but subsequently, its overexpression has been demonstrated in various solid malignancies.

TROP2 is overexpressed in different tumor tissues and plays roles in cell proliferation, invasion, migration, apoptosis, and treatment resistance by binding to or interacting with several molecules. As a therapeutic target, TROP2 is particularly suitable for antibody-based therapies.