
Trop2 and its overexpression in cancers: regulation and clinical ...
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival. It has stem cell-like qualities.
TACSTD2 - Wikipedia
Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1) [5] is a protein that in humans is encoded by the TACSTD2 gene. [6] [7] [8] This intronless gene is located at the short arm of chromosome 1 (1p32.1). [9] It encodes a carcinoma-associated antigen defined by the monoclonal ...
Overview of Trop-2 in Cancer: From Pre-Clinical Studies to Future ...
Trophoblast cell surface antigen-2 (Trop-2) is a glycoprotein that was first described as a membrane marker of trophoblast cells and was associated with regenerative abilities. Trop-2 overexpression was also described in several tumour types.
Trop-2 protein as a therapeutic target: A focused review on Trop-2 ...
Trop-2 (also called epithelial glycoprotein-1, gastrointestinal antigen 733-1, membrane component surface marker-1, and tumor-associated calcium signal transducer-2), is a product of the TACSTD2 gene located at 1p32.1 reviewed in Goldenberg et al. [1].
Targeting Trop-2 in cancer: Recent research progress and clinical ...
2023年7月1日 · Trophoblast surface antigen 2 (Trop-2) is a type I transmembrane glycoprotein involved in Ca 2+ signaling in tumor cells. It is highly expressed in various tumor tissues than in normal tissues and represents a novel and promising molecular target for caner targeted therapy.
Trop2 and its overexpression in cancers: regulation and clinical ...
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival. It has stem cell-like qualities.
Trop-2 Directed Antibody-Drug Conjugates for the Treatment of …
2022年2月25日 · This article provides an overview of antibody-drug conjugates for the treatment of solid tumors and examines emerging evidence demonstrating Trop-2 as a potential target in breast and lung...
A new TROP2-targeting antibody-drug conjugate shows potent
2024年4月23日 · Trophoblast cell surface antigen 2 (Trop2) is considered to be an attractive therapeutic target in cancer treatments. We previously generated a new humanized anti-Trop2 antibody named...
Trop-2 protein as a therapeutic target: A focused review on Trop-2 ...
2022年2月1日 · Trophoblast cell-surface antigen-2 (Trop-2) was originally described in trophoblasts and fetal tissues, but subsequently, its overexpression has been demonstrated in various solid malignancies.
A literature review of the promising future of TROP2 - PubMed …
TROP2 is overexpressed in different tumor tissues and plays roles in cell proliferation, invasion, migration, apoptosis, and treatment resistance by binding to or interacting with several molecules. As a therapeutic target, TROP2 is particularly suitable for antibody-based therapies.