2022年3月17日 · What is a troponin test? A troponin test looks for the protein troponin (there are two forms related to your heart, troponin I and troponin T) in your blood. Normally, troponin stays inside your heart muscle’s cells, but damage to those cells — like the kind of damage from a heart attack — causes troponin to leak into your blood.

2023年6月30日 · Datopotamab binds to a protein found on cancer cells called TROP2; it then goes inside and releases the DXd payload to kill the tumor cells. DXd may leak out to surrounding cancer cells and kill those as well. The TROPION-Breast01 study is comparing Dato-DXd with standard-of-care chemotherapy.

2025年2月5日 · Objectives: The primary objective of TROPION-Breast04 is to evaluate the efficacy and safety of neoadjuvant Dato-DXd plus durvalumab followed by adjuvant durvalumab with or without chemotherapy versus standard of care in patients with previously untreated early-stage TNBC or HR-low/HER2- breast cancer.

2024年4月29日 · Objectives: TROPION-Breast03 is an ongoing phase III study evaluating the efficacy and safety of Dato-DXd alone or combined with durvalumab versus standard-of-care therapy as adjuvant treatment in patients with stage I-III TNBC with residual invasive disease at surgical resection following neoadjuvant treatment.

2024年9月12日 · Here, we report the primary results from the phase 3 TROPION-Breast01 study, which evaluated Dato-DXd versus investigator's choice of chemotherapy (ICC) in patients with inoperable or metastatic HR+/HER2– breast cancer who had received one or two previous lines of chemotherapy in this setting.

2023年3月15日 · Troponins are proteins released into the bloodstream if there’s heart damage. Lab results below the 99th percentile mean normal function. Higher levels could mean a heart …

2025年1月30日 · TROPION-Lung12 is a global, multicenter, three-arm, open-label phase 3 trial where patients will be randomized in a 2:1:2 ratio to evaluate the efficacy and safety of adjuvant DATROWAY (6 mg/kg) in combination with rilvegostomig (750 mg) or rilvegostomig (750 mg) monotherapy versus observation or standard of care adjuvant chemotherapy regimens i...

2022年6月13日 · A comprehensive development program called TROPION is underway globally with trials evaluating the efficacy and safety of datopotamab deruxtecan across multiple solid tumors, including TNBC, HR positive/HER2 negative breast cancer, non-small cell lung cancer, small cell lung cancer, urothelial, gastric and esophageal cancer.

2024年9月28日 · Troponin is a type of protein found in heart muscle but not typically found in the blood. However, when the heart is damaged, this protein is released into the bloodstream. Even a slight increase in your troponin level can signal some damage to the heart. Very high levels of troponin indicate that a heart attack has occurred.

2023年6月1日 · Troponins describe a group of proteins that are normally only found in the skeletal muscles and heart but can leak into the bloodstream if the heart becomes damaged. These proteins help regulate muscle contractions and functions of …