2009年11月1日 · TSHR is the receptor for thyrotropin (thyroid stimulating hormone or TSH), a member of the glycoprotein hormone family. TSH is released by the anterior pituitary gland and is the main regulator of thyroid gland growth and development.

2024年8月27日 · Located between the cap structure and start codon, the 5′UTR binds to various transcription factors and ribosomes, thereby regulating initiation, scanning, and selection in mRNA translation 11.

2022年12月23日 · Here, we use Nanopore long-read sequencing and cap analysis of gene expression (CAGE-seq) to document the landscape of 5′ and 3′ untranslated region (UTR) isoforms and transcription start sites of...

Precise control of protein synthesis by engineering sequence elements in 5' untranslated regions (5' UTRs) remains a fundamental challenge. To accelerate our understanding of the cis-regulatory code embedded in 5' UTRs, we devised massively parallel reporter assays from a synthetic messenger RNA library composed of over one million 5' UTR variants.

与天然5'UTR翻译效率比较. 测定α-globin 5' UTR和β-globin 5' UTR翻译效率，结果发现在活细胞中，α-globin 5' UTR拥有最高的翻译效率，这与1994年Kozak在体外系统得到的结果是相反的（β-globin 5' UTR翻译效率要高于α-globin 5' UTR）。而且，还可以发现，globin UTRs翻译效率要 ...

2024年4月5日 · The NCA-7d-5′UTR, an optimized 5′ UTR for protein-coding mRNAs, has demonstrated effective delivery via lipid-derived TT3 nanoparticles, resulting in pronounced expression of potential SARS ...

In this review we will summarize recent advances in our understanding of the mechanisms by which the key immune-related genes, HLA-DR3 and CD40, and thyroid-specific genes, Tg and TSHR, trigger AITD. We will highlight how the newly discovered mechanisms underlying the development of AITD are guiding therapeutic advancements.

2022年4月13日 · The TSH receptor (TSHR) is a member of the glycoprotein hormone receptors, a subfamily of family A G protein-coupled receptors. The TSHR is of great importance for the growth and function of the thyroid gland. The TSHR and its endogenous ligand TSH are pivotal proteins with respect to a variety of physiological functions and malfunctions.

研发人员为合成出携带7种不同的最短5'UTR序列的mRNA，将翻译起始密码子上游的T7启动子序列（TAATACGACTCTATA）和Kozak保守元件(Kozak consensus sequence，是位于真核生物mRNA 5’端帽子结构后面的一段核酸序列，通常是GCCACC，它可以与翻译起始因子结合而介导含 …

2020年7月29日 · 系统研究5'utr中顺式调节元件将有助于揭示翻译起始与mrna降解之间的逻辑和机制关系。 通过在5'非翻译区（5'UTR）中系统改变序列元件来精确控制蛋白质合成也仍然是一个难题。