2017年7月24日 · We here summarize current knowledge regarding naturally occurring TSHR mutations, associated diseases and related molecular pathogenic mechanisms at the level of TSHR structure and function. For complete coverage of this and related areas in Endocrinology, visit our free web-books, www.endotext.org and www.thyroidmanager.org.

2024年12月25日 · TSHR (Thyroid Stimulating Hormone Receptor) is a Protein Coding gene. Diseases associated with TSHR include Hyperthyroidism, Familial Gestational and Hypothyroidism, Congenital, Nongoitrous, 1. Among its related pathways are Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling.

The TSHR gene provides instructions for making a protein, known as a receptor, that attaches (binds) to a hormone called thyroid stimulating hormone (TSH). Learn about this gene and related health conditions.

The thyroid stimulating hormone receptor (TSHR) is the key regulator of thyrocyte function. The gene for the TSHR on chromosome 14q31 has been implicated as coding for the major autoantigen in the autoimmune hyperthyroidism of Graves' disease (GD) ...

Thyroid stimulating hormone receptor (TSHR) is a receptor for thyrostimulin and thyroid stimulating hormone (TSH, also called thyrotropin) [1]. TSHR is a cell surface glycoprotein receptor and belongs to the leucine-rich repeat (LGR) …

Data indicate the structural integrity of thyroid stimulating hormone receptor isoform (TSHR) and its potential binding of thyroid stimulating hormone (TSH). TSHR protein was detected on human EOM myoblasts and increasing TSHR expression during myogenic differentiation.

The TSHR gene provides instructions for making a protein, known as a receptor, that attaches (binds) to a hormone called thyroid stimulating hormone (TSH). This receptor spans the membrane of certain cells (called follicular cells) in the thyroid gland, a …

2024年6月17日 · The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase.

The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by Adenylate Cyclase .

2024年9月18日 · Genetic defects in the TSH receptor (TSHR) can cause poor thyroid differentiation (thyroid dysgenesis) and/or thyroid malfunction (thyroid dyshormonogenesis). The phenotype spectrum is wide: from severe congenital hypothyroidism to mild hyperthyrotropinemia. Over 250 TSHR variants have been published, many uncharacterized in vitro.