Vibration-controlled transient elastography was performed to evaluate the severity of hepatic fibrosis and steatosis using LS and controlled attenuation parameter (CAP), respectively.

2021年6月28日 · Baseline serum TSP2 level was significantly associated with incident ≥F3 fibrosis (OR 2.82, P = 0.005), independent of other significant clinical risk factors of fibrosis progression, including BMI, platelet count, and CAP at baseline.

2022年11月7日 · Among several secreted glycoproteins belonging to the thrombospondin family, thrombospondin 2 (TSP2) is involved in various functions, including collagen/fibrin formation. Liver/serum TSP2...

基线血清 tsp2 水平与发生 ≥f3 纤维化显着相关（or 2.82，p = 0.005），独立于纤维化进展的其他重要临床危险因素，包括基线时的 bmi、血小板计数和 cap。 结论

2023年12月21日 · Baseline circulating thrombospondin-2 (TSP2) level was identified as a potential novel hepatic fibrosis biomarker that associates with development and progression of hepatic fibrosis in patients with nonalcoholic fatty liver disease and type 2 diabetes.

使用振动控制瞬态弹性成像技术测量肝脏硬度（LS）和受控衰减参数（CAP），分别用于评估肝纤维化和脂肪变性。 结果：在这 60 名基线时具有相似临床特征（平均 HbA1c 8.9%、CAP 289 dB/m 和 LS 5.9 kPa）的参与者中，尽管 HbA1c 降低程度相似，但达格列净而非西他列汀治疗导致体重 (BW) 显着改善24 周后 (p=0.012)、CAP (p=0.015) 和 LS (p=0.011)。 血清 TSP2 水平从 3.07 ng/mL 显着降低至 2.90 ng/mL (p=0.012)，而西他列汀未观察到 TSP2 显着变化。

2023年12月21日 · Baseline serum TSP2 level was significantly associated with incident ≥F3 fibrosis (OR 2.82, P = 0.005), independent of other significant clinical risk factors of fibrosis progression, including...

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2023年6月20日 · Liver stiffness (LS) and controlled attenuation parameter (CAP) were measured using vibration-controlled transient elastography for evaluation of hepatic fibrosis and steatosis, respectively.

2014年8月1日 · TSP2 functions primarily as a modulator of cell–ECM interactions and can influence the assembly of ECM. More importantly, TSP2-null ECM enhances angiogenic responses. Therefore, strategies can be pursued to reduce TSP2 and generate novel ECM via decellularization techniques.