EGFR signaling promotes nuclear translocation of plasma …
2022年2月23日 · Here, we demonstrate that, epidermal growth factor receptor (EGFR) signaling induces TSPAN8 nuclear translocation by activating the kinase AKT, which in turn directly …
TSPAN8 promotes cancer cell stemness via activation of sonic
2019年6月28日 · Here, we report that TSPAN8 expression is upregulated in breast CSCs, promotes the expression of the stemness gene NANOG, OCT4, and ALDHA1, and correlates …
泛实体瘤治疗新靶点—TSPAN8 - 知乎 - 知乎专栏
研究报道， TSPAN8在胃肠道（包括食管、胃、小肠和大肠）以及一些生殖器官（如卵巢和睾丸）中呈强表达，TSPAN8是一种肿瘤相关抗原，在多种癌细胞系中表达，包括结直肠癌、胃癌 …
Targeting the Tetraspanins with Monoclonal Antibodies in …
These in-vivo data underlined the crucial role of Tspan8 in tumor growth and the therapeutic potential of anti-Tspan8 mAbs as a CRC treatment. The discrepancy between the in-vitro and …
TSPAN8 + myofibroblastic cancer–associated fibroblasts promote …
2024年4月3日 · Here, we performed a single-cell analysis using high-dimensional flow cytometry analysis and identified a distinct senescence-like tetraspanin-8 (TSPAN8) + myofibroblastic …
TSPAN8 as a Novel Emerging Therapeutic Target in Cancer for
2020年3月3日 · Tetraspanin 8 (TSPAN8) is a member of the tetraspanin superfamily that forms TSPAN8-mediated protein complexes by interacting with themselves and other various cellular …
Cell Res | 上海交通大学王红霞团队发现TSPAN8核转位可增强肿瘤 …
2022年2月23日，上海交通大学王红霞团队在Cell Research发表题为「 EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via …
Tspan8 Is Highly Expressed in Clear Cell Renal Cell Carcinoma and ...
Methods: Tspan8 expression was detected in 150 cases of ccRCC and matched paracancerous tissues by immunohistochemistry (IHC) and its relevance with prognosis was analyzed. …
High TSPAN8 expression in epithelial cancer cell-derived small
Functional assays indicated that the transgenic TSPAN8-sEV cargo increased cancer cell motility and epithelial-mesenchymal transition (EMT). In vivo, transgenic TSPAN8-sEV promoted …
EGFR signaling promotes nuclear translocation of plasma …
Here, we demonstrate that, epidermal growth factor receptor (EGFR) signaling induces TSPAN8 nuclear translocation by activating the kinase AKT, which in turn directly phosphorylates …