A tumor (neoplasm) is a solid mass of tissue that forms when abnormal cells group together. They can form most anywhere in your body, including your bones, skin, tissue, organs and glands. …

2024年3月19日 · Changes in molecular-level, cellular-level and tissue-level mechanical properties across multiple timescales and dimensions play a critical role in driving oncogenesis, tumour …

Understanding the complex ways in which cancer cells interact with their surroundings, both locally in the tumor organ and systemically in the body as a whole, has implications for …

2025年1月15日 · Recently, we proposed four physical hallmarks of cancer, with distinct origins and consequences, to characterize abnormalities in the physical tumor microenvironment: (1) …

2023年10月20日 · Solid tumors and their associated tumor microenvironment (TME) consist of tumor cells and stromal components, including extracellular matrix (ECM), basement …

Morphological and functional characteristics of the malignant cell. Morphologically, the cancerous cell is characterized by a large nucleus, having an irregular size and shape, the nucleoli are …

Although some tumors (eg, leukemias, ascites tumors) grow as cell suspensions, most tumors grow as solid masses of tissue. Solid tumors have a distinct structure that mimics that of …

2024年7月29日 · A tumor, or neoplasm, is abnormal tissue that develops because of excessive cell growth. Tumors can be either benign (noncancerous) or malignant (cancerous and likely to …

2025年3月12日 · Tumors often exhibit greater stiffness compared to normal tissues, primarily due to increased deposition within the tumor stroma. Collagen, proteoglycans, laminin, and …

3 天之前 · Tumor cell-derived OPN positively correlated with the degree of tumor stromal fibrosis. (A) Representative immunohistochemical (IHC) staining images (left, scale bars = 20 μm) and …