Polyketide synthase - Wikipedia
Type III PKSs are small homodimers of 40 kDa proteins that combine all the activities from the essential type I and II PKS domains. However, in contrast to type I and II PKSs they do not …
Type I Polyketide Synthases That Require Discrete Acyltransferases
Polyketides constitute one of the largest families of natural products and many are biosynthesized by noniterative type I polyketide synthases (PKSs). Type I PKSs are multifunctional enzymes …
顺式和反式-AT型聚酮合酶研究进展及应用
聚酮类化合物结构多种多样，核心结构均由简单脂肪酸在聚酮合酶(Polyketide Synthase，PKS)催化下经过类似长链脂肪酸的合成途径生成，经过氧化、糖基化和甲基化后才能赋予代谢物生物 …
The architectures of iterative type I PKS and FAS
Type I fatty acid synthases (FASs) are giant multienzymes catalyzing all steps of the biosynthesis of fatty acids from acetyl- and malonyl-CoA by iterative precursor extension. Two strikingly …
Regulation and manipulation of the gene clusters encoding type-I …
2000年6月1日 · Based on their gene sequences and the conformation of their constituent proteins, PKSs can be divided into two groups: modular and iterative. Iterative PKSs, also …
Ⅰ型聚酮合酶中酰基转移酶结构域的研究进展
Abstract: Most polyketide natural compounds, such as antibiotics, antineoplastics and immunosuppressants, are produced by type Ⅰ polyketide synthases (PKSs). Type Ⅰ PKSs …
The architectures of iterative type I PKS and FAS - PubMed
2018年10月17日 · PKSs produce a variety of complex and potent secondary metabolites; they either act iteratively (iPKS), or are linked via directed substrate transfer into modular assembly …
Iterative polyketide biosynthesis by modular polyketide synthases …
2015年11月9日 · Modular polyketide synthases (type I PKSs) in bacteria are responsible for synthesizing a significant percentage of bioactive natural products. This group of synthases …
Metagenomic data reveals type I polyketide synthase ... - mSystems
2023年6月5日 · Here, we used the web tool NaPDoS2 to assess type I polyketide synthase (PKS) diversity and distributions by detecting and classifying ketosynthase (KS) domains across 137 …
上海交大邓子新团队受邀撰写NPR封面文章——迭代式Ⅰ型聚酮合 …
2023年9月28日 · 科研人员正迫切期待着进一步理解type I iPKSs，最终创造具备可编程功能的分子机器，产生个性化、定制化的终产物与新型药物。 该研究得到了国家重点研究发展计划、国 …
Type I polyketide synthase requiring a discrete acyltransferase for ...
2003年2月21日 · Type I polyketide synthases (PKSs) are multifunctional enzymes that are organized into modules, each of which minimally contains a β-ketoacyl synthase, an …
Structural and evolutionary relationships of “AT-less” type I ...
2015年9月29日 · Acyltransferase (AT)-less type I polyketide synthases (PKSs) break the type I PKS paradigm. They lack the integrated AT domains within their modules and instead use a …
Modular type I polyketide synthase acyl carrier protein ... - Nature
2019年2月20日 · Polyketides are constructed from simple carboxylic acid-derived components, often by filamentous bacteria using modular type I polyketide synthases (PKSs), gigantic …
Unraveling the iterative type I polyketide synthases hidden in
2020年3月26日 · Type I polyketide synthases (T1PKSs) are one of the most extensively studied PKSs, which can act either iteratively or via an assembly-line mechanism. Domains in the …
Structure of a modular polyketide synthase | Nature
2014年6月18日 · Their biosynthetic machinery, represented by type I polyketide synthases (PKSs), has an architecture in which successive modules catalyse two-carbon linear …
The structures of type I polyketide synthases - RSC Publishing
With the recent structural characterization of each of the component enzymes of type I polyketide synthases, scientists are coming tantalizingly close to elucidating the overall architectures and …
The structure of a polyketide synthase bimodule core
2022年9月21日 · Polyketide synthases (PKSs) are predominantly microbial biosynthetic enzymes. They assemble highly potent bioactive natural products from simple carboxylic acid …
Engineering of PKS Megaenzymes—A Promising Way to
2021年9月4日 · In particular for type-I iterative PKSs, a phylogenetic analysis of the class in fungi showed that groups of genes encoding iterative PKS systems fall into eight groups: four …
Polyketide biosynthesis beyond the type I, II and III polyketide ...
2003年4月1日 · Since the first reports of bacterial type I PKS in 1990 4., 5., type II PKS in 1984 6., 7., and type III PKS in 1999 [8], the PKS paradigms have served the scientific community …
Jay Keasling开发PKS模块化生物合成平台，实现二醇等高效合成|辅 …
2025年2月21日 · I 型聚酮合酶（Type I PKS）作为一类高度模块化的酶系统，在自然界中负责合成多种复杂次级代谢产物，如抗生素、免疫抑制剂和其他生物活性分子。