2024年12月25日 · TYROBP (Transmembrane Immune Signaling Adaptor TYROBP) is a Protein Coding gene. Diseases associated with TYROBP include Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1 and Dementia. Among its related pathways are Innate Immune System and Nervous system development.

TYRO protein tyrosine kinase -binding protein is an adapter protein that in humans is encoded by the TYROBP gene. [5][6] This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain.

该基因内的突变与多囊性脂膜性骨发育不良伴硬化性白质脑病 (PLOSL) ，也称为 Nasu-Hakola 病有关。 其推定的受体，即髓样细胞 2 (TREM2) 上表达的触发受体，也会引起 PLOSL。 已经为该基因鉴定了编码不同亚型的多个替代转录物变体。 [RefSeq 提供，2010 年 3 月] This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain.

TREM1（Triggering receptor expressed on myeloid cells-1）是一种在中性粒细胞、单核细胞、巨噬细胞表面表达的髓系细胞表面受体，在多种肿瘤微环境中均表达，协同经典的 模式识别受体 （PRR），例如Toll-like受体（TLR）家族和Nod-like受体（NLR）家族，在宿主防御中放大由微生物成分介导的炎症反应。 通过抗TREM1抗体将肿瘤相关髓系细胞群上的细胞表面TREM1交联，可引起下游信号传导，从而诱导一组特定的促炎细胞因子和趋化因子的分泌，并增加HLA-DR …

2024年8月30日 · Immune infiltration correlation analysis shows that the top-ranked signature gene, Tyrobp, is negatively correlated with M2 macrophages and plasma cells, and Western blot analysis shows higher ...

TYROBP（也称为 DAP12 或 KARAP）是一种跨膜衔接蛋白，最初被描述为自然杀伤 (NK) 细胞的受体激活亚基成分。 TYROBP 在多种细胞类型中表达，包括外周血单核细胞、巨噬细胞、树突状细胞和破骨细胞，但最近人们感兴趣的一个关键点是 TYROBP 在小胶质细胞质膜上表达的许多受体的功能中发挥的关键作用。 TYROBP 是与阿尔茨海默病 (AD) 相关的几种受体的下游接头和假定的信号传导伙伴，包括 SIRP1β、CD33、CR3 和 TREM2。 TYROBP 目前已声名狼藉，因为 …

The TYROBP gene provides instructions for making the TYRO protein tyrosine kinase binding (TYROBP) protein. This protein is found in a variety of cells that are produced in bone marrow (myeloid cells) and other immune system cells (lymphoid cells).

TYROBP is a potential prognostic biomarker of clear cell renal cell carcinoma. Non-pathological roles of microglial TREM2/DAP12: TREM2/DAP12 regulates the physiological functions of microglia from development to aging. Elevated TYROBP expression predicts poor prognosis and high tumor immune infiltration in patients with low-grade glioma.

2025年2月19日 · Clinical resource with information about TYROBP, Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

DAP12 (DNAX-activating protein 12)/TYROBP, a molecule localized to microglia, is a direct partner/adapter for TREM2, CD33, and CR3. We and others have previously shown that TYROBP expression is increased in AD patients and in mouse models. Moreover, missense mutations in the coding region of TYROBP have recently been identified in some AD patients.