我们知道DNA的甲基化修饰是发生在胞嘧啶（C）上的，而最常见的RNA的甲基化修饰是 m6A （N6-methyladenosine，6-甲基腺嘌呤）和 尿苷化修饰 （uridylation，U-tail）。 m6A修饰在70年代就发现了，是可以发生在mRNA、lncRNA等RNA的腺嘌呤（A）上的甲基化修饰，在哺乳动物中，发生 m6A修饰的腺嘌呤A比例为0.1–0.4%，算起来每条mRNA只有3-5个m6A甲基化位点。 而U-tail是发生在. RNA的尿嘧啶修饰，通常与RNA的降解过程有关。 哺乳动物和酵母中的m6A位 …

2018年9月21日 · Two recent studies reveal new roles of uridylation in immune defense against viruses and retrotransposons. Tailing (3′-terminal addition of untemplated nucleotides) occurs on virtually all types of...

2014年8月28日 · This Minireview summarizes the molecular machineries and biological functions of methylation (N6-methyladenosine, m 6 A) and uridylation (U-tail). RNAs undergo chemical modifications that can affect their activity, localization, and stability (Machnicka et al., 2013), which is conceptually analogous to the modifications of DNA and protein.

2014年8月28日 · Recent developments have unveiled that at least some of the modifications are considerably abundant and widely conserved. This Minireview summarizes the molecular machineries and biological functions of methylation (N6-methyladenosine, m (6)A) and uridylation (U-tail). Copyright © 2014 Elsevier Inc. All rights reserved.

This Minireview summarizes the molecular machineries and biological functions of methylation (N6-methyladenosine, m6A) and uridylation (U-tail). RNAs undergo chemical modifications that can affect their activ-ity, localization, and stability (Machnicka et al., 2013), which is conceptually analogous to the modifications of DNA and protein.

2014年9月4日 · 8月28日出版的Cell中，首尔大学的研究者发布综述，介绍了N6-甲基腺苷化修饰 (N6-methyladenosine, m 6 A)，以及尿苷化修饰 (uridylation，U-tail)这两种最常见RNA修饰方式的分子机制和生物学功能。 m 6 A这种修饰方式是康奈尔大学维尔医学院的研究人员在2012年发现的，当时研究人员发现，在超过20%的人群中，超过5000种不同的mRNA的腺嘌呤的碱基上会被添加一个甲基 (methyl group)，形成m 6 A修饰。 而这些mRNA中很多是人类疾病相关的基因转录 …

There may be no better all-around worm on the market today than the U-Tale, the perfect mid-size body for the widest variety of conditions, paired with a flapping curly tail which forms the letter “U.” It’s a proven fish catcher anywhere that bass swim – has been for generations and will continue to be so for the foreseeable future.

2020年6月1日 · In this Review, we discuss recent advances in our understanding of non-canonical RNA tails, with a focus on the functions of human TENTs, which include uridylation, mixed tailing and...

Nat Struct Mol Biol. 2018 Oct;25 (10):903-905. doi: 10.1038/s41594-018-0139-0. 1 Center for RNA Research, Institute for Basic Science, Seoul, Korea.

Our data suggest that interaction of the newly synthesized poly(U) tail of the gRNA with the purine-rich region of the mRNA protects the gRNA 3′ tail from editing complex-associated 3′ U-specific exonuclease activity.