U.S. Route 78 (US 78) is an east–west United States Numbered Highway that runs for 843.6 miles (1,357.6 km) from Swifton, Arkansas, to Charleston, South Carolina. From Byhalia, Mississippi to Graysville, Alabama, US 78 runs concurrently with Interstate 22 (I-22).

U.S. Route 78 (US 78) is a 142.207-mile (228.860 km) U.S. highway that travels from Swifton, Arkansas to Charleston, South Carolina. In the U.S. state of South Carolina, it travels from the Savannah River at North Augusta to its eastern terminus in Charleston; connecting the cities of Aiken, Summerville, and North Charleston.

U.S. Route 78 (US 78) is a major east–west U.S. Highway across the central part of Alabama. It is internally designated State Route 4 (SR 4) by the Alabama Department of Transportation (ALDOT), though the only section of SR 4 that is signed is along portions mainly west of Jasper.

2021年9月25日 · Accompanying a Norfolk Southern Railroad line, U.S. 78 advances east to Reevesville, I-95 and Saint George in northern Dorchester County. Through the South Carolina's LowCountry, U.S. 78 parallels Interstate 26, from the south end of U.S. 178 to Summerville. U.S. 78 shifts east of the freeway to Goose Creek, where it combines with U.S. 52.

2024年7月9日 · US route 78 has endpoints in Charleston (South Carolina) and Memphis (Tennessee).

2020年12月8日 · U.S. Highway 78 (also known as U.S. Route 78 or Bankhead Highway) currently runs for 715 miles from I-240 in Memphis, Tennessee to US 17 in Charleston, South Carolina. In Alabama the route is paired with unsigned Alabama State Highway 4. Much of the route east of Birmingham to Augusta, Georgia is paralleled by I-20.

美国78号公路替代（ us 78 alt。 ）是美国78号在阿拉巴马州东北部和佐治亚州西北部的替代路线。它包括从阿拉巴马州赫夫林到佐治亚州的阿拉巴马州46号公路（sr 46）的当前长度，从州线到卡罗尔顿的sr 166 ，以及从 卡罗尔顿到维拉·里卡的 sr 61 。

2017年8月13日 · US 78 was widened for about a mile east of US 321 by 2008. Comment: US 78 follows the first railroad in the U.S., connecting many towns along the way - Williston, Blackville, Bamberg, Branchville, St. George, and Summerville. US 78 is not that well traveled anymore because of all the towns.

U.S. Route 78 is an east–west highway. It goes from Memphis, Tennessee to Charleston, South Carolina.

Respondent inmates brought a class action challenging two regulations promulgated by the Missouri Division of Corrections.