2018年4月20日 · Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondria-ER appositions …

2022年1月19日 · Using proximity-ligation assays, we show that Mfn2 specifically co-localizes with PINK1 and phospho-ubiquitin (pUb) in U2OS cells upon mitochondrial depolarization. We …

2018年8月21日 · We found that ubiquitination of MFN2 by PRKN occurs rapidly at the onset of mitophagy compared to other PRKN substrates on the OMM, an effect that we are able to …

2025年2月10日 · Here we identify a role of MFN2 in quality control independent of its function in organellar shape remodeling. MFN2 ablation alters the cellular proteome, marked for example …

2013年7月11日 · We report here that MITOL regulates mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) domain formation through mitofusin2 (Mfn2). MITOL …

2011年3月8日 · Mfn2 – mitofusin 2; Ub-Mfn2 – ubiquitinated mitofusin 2. To determine the subcellular localization of ubiquitinated Mfn1 and 2 in control fibroblasts, cells were incubated …

2020年8月25日 · Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages …

2018年12月1日 · Mitochondrial pro-fusion protein Mitofusins (Mfn1 and Mfn2) were found to be a target for Parkin mediated ubiquitination. Mfns are transmembrane GTPase embedded in the …

Mitofusin-2 (Mfn2) is a highly conserved transmembrane GTPase which plays a critical role in mitochondrial fusion process. Recent data have been demonstrated that Mfn2 is involved in …

2012年8月24日 · In this study we examine the relationship between Mfn2 and stress-induced apoptosis. We establish that Mfn2 is a substrate for Jun N-terminal kinase (JNK), which …