
Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent ... - eLife
2018年4月20日 · Here we describe a mechanism by which Mfn2, a mitochondria-ER tether, gates the autophagic turnover of mitochondria by PINK1 and parkin. Mitochondria-ER appositions …
Selective localization of Mfn2 near PINK1 enables its preferential ...
2022年1月19日 · Using proximity-ligation assays, we show that Mfn2 specifically co-localizes with PINK1 and phospho-ubiquitin (pUb) in U2OS cells upon mitochondrial depolarization. We …
MFN2 retrotranslocation boosts mitophagy by uncoupling …
2018年8月21日 · We found that ubiquitination of MFN2 by PRKN occurs rapidly at the onset of mitophagy compared to other PRKN substrates on the OMM, an effect that we are able to …
Mitofusin 2 displays fusion-independent roles in proteostasis ...
2025年2月10日 · Here we identify a role of MFN2 in quality control independent of its function in organellar shape remodeling. MFN2 ablation alters the cellular proteome, marked for example …
MITOL Regulates Endoplasmic Reticulum-Mitochondria Contacts …
2013年7月11日 · We report here that MITOL regulates mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) domain formation through mitofusin2 (Mfn2). MITOL …
Mutations in PINK1 and Parkin Impair Ubiquitination of …
2011年3月8日 · Mfn2 – mitofusin 2; Ub-Mfn2 – ubiquitinated mitofusin 2. To determine the subcellular localization of ubiquitinated Mfn1 and 2 in control fibroblasts, cells were incubated …
Mitofusin 2 in Macrophages Links Mitochondrial ROS Production ... - PubMed
2020年8月25日 · Mitofusin 2 (Mfn2) plays a major role in mitochondrial fusion and in the maintenance of mitochondria-endoplasmic reticulum contact sites. Given that macrophages …
Regulation of ER-mitochondria contacts by Parkin via Mfn2
2018年12月1日 · Mitochondrial pro-fusion protein Mitofusins (Mfn1 and Mfn2) were found to be a target for Parkin mediated ubiquitination. Mfns are transmembrane GTPase embedded in the …
线粒体融合蛋白2研究新进展 - pibb.ac.cn
Mitofusin-2 (Mfn2) is a highly conserved transmembrane GTPase which plays a critical role in mitochondrial fusion process. Recent data have been demonstrated that Mfn2 is involved in …
Stress-Induced Phosphorylation and Proteasomal Degradation
2012年8月24日 · In this study we examine the relationship between Mfn2 and stress-induced apoptosis. We establish that Mfn2 is a substrate for Jun N-terminal kinase (JNK), which …
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