2024年12月25日 · UBC (Ubiquitin C) is a Protein Coding gene. Diseases associated with UBC include Machado-Joseph Disease and Middle East Respiratory Syndrome. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Toll Like Receptor 7/8 (TLR7/8) Cascade.

Polyubiquitin-C is a protein encoded by the UBC gene in humans. [5] [6] [7] Polyubiquitin-C is one of the sources of ubiquitin, along with UBB, UBA52, and RPS27A. [8] UBC gene is one of the two stress-regulated polyubiquitin genes (UBB and UBC) in mammals. It plays a key role in maintaining cellular ubiquitin levels under stress conditions.

2025年2月9日 · This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated.

This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubi quitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated.

This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or Polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated.

2022年8月16日 · We used a publicly available RNA-seq database to perform an extensive genome-wide gene expression analysis of the core components of the ubiquitination machinery, covering Ub genes as well as E1, E2, E3 and DUB genes.

In mice, polyubiquitin genes (Ubb and Ubc) play a pivotal role to meet the requirement of cellular Ub pools during embryonic development. In addition, expression levels of polyubiquitin genes are increased to adapt to environmental stimuli such as oxidative, heat-shock, and proteotoxic stress.

2019年12月6日 · Our findings suggest how increasing cellular ubiquitin levels may control the expression of UBC gene by negatively affecting the splicing of its pre-mRNA, providing a straightforward feedback...

Discover the molecular mechanisms behind Ubiquitin C (UbC) gene expression and its role in cellular stress response. Explore its structure, function, and transcriptional regulation in this comprehensive review.

Gene ID: 7316, updated on 9-Feb-2025. This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated.